Cancer in the offspring of female radiation workers: a record linkage study.

British Journal of Cancer
K J BunchW Zhang

Abstract

This study uses record linkage between the National Registry of Childhood Tumours (NRCT) and the National Registry for Radiation Workers to re-assess our earlier finding that the offspring of women radiation workers exposed to ionising radiation before the child's conception may be at an increased risk of childhood cancer. An additional 16,964 childhood cancer patients taken from the NRCT, together with the same number of matched controls, are included. Pooled analyses, based on the new and original datasets, include 52,612 cases and their matched controls. Relative risks (RRs) for maternal employment as a radiation worker, maternal exposure or not during the relevant pregnancy and pattern of employment relative to conception and diagnosis dates were calculated.The new data provide no evidence of an increased risk of childhood cancer associated with maternal preconception radiation work and thus do not support our earlier finding of a raised risk in the offspring of female radiation workers. Considering the pooled data, a weak association was found between maternal radiation work during pregnancy and childhood cancer in offspring although the evidence is limited by the small numbers of linked cases and controls.

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Citations

Jun 15, 2011·Statistical Methods in Medical Research·Xiaochun Li, Changyu Shen
Aug 23, 2018·British Journal of Cancer·Gerald M KendallTim J Vincent
Nov 18, 2016·British Journal of Cancer·Joachim SchüzAlexander V Akleyev
Jan 9, 2013·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Richard Wakeford
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ashok KumarRadha Rathee
Nov 8, 2019·Prenatal Diagnosis·Sandra A Lowe
Apr 1, 2021·International Journal of Radiation Biology·Richard Wakeford, John F Bithell
Jul 11, 2021·Pediatric Research·Yuhki KogaUNKNOWN Japan Environment and Children’s Study (JECS) Group
Aug 7, 2021·International Journal of Radiation Biology·Jill Sutcliffe

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