PMID: 11296146Apr 11, 2001

Cancer incidence after childhood nasopharyngeal radium irradiation: a follow-up study in Washington County, Maryland

American Journal of Epidemiology
H YehG W Comstock


A population from a hearing clinic in Washington County, Maryland, in 1943-1960 was followed to assess the risk of developing neoplasms from radium treatment of the nasopharynx for adenoid hypertrophy. Of the 2,925 subjects who attended the clinic, 904 received radium treatment. A nonconcurrent prospective study compared the cancer incidence among the irradiated persons with that among persons with other treatments. Seven brain tumor cases (three malignant and four benign) were identified in the irradiated group versus none in the nonirradiated group (relative risk = 14.8, 95% confidence interval: 0.76, 286.3). A nonsignificant excess risk of thyroid cancer was detected in the irradiated group based on two cases in the exposed group and one case in the nonexposed group (relative risk = 4.2, 95% confidence interval: 0.38, 46.6). Decreased risks of breast cancer, female genital cancers, and prostate cancer were observed among the irradiated individuals, although these deficits were not statistically significant individually. The decreased risk of sex hormone-related cancers in the irradiated group suggests possible radiation damage to the pituitary, with consequent reduction in pituitary hormone output and alterations in sexual a...Continue Reading


May 18, 2004·Cancer Treatment Reviews·Barbara A Jereczek-FossaRoberto Orecchia
Dec 11, 2003·Annals of Epidemiology·Cécile M RonckersFlora E Van Leeuwen
Jul 3, 2013·The Lancet Oncology·Daniel C BowersLisa Bashore
Jul 5, 2001·Journal of the National Cancer Institute·Cécile M RonckersFlora E Van Leeuwen
Sep 7, 2012·Neuro-oncology·Melissa Z BraganzaPreetha Rajaraman
Sep 17, 2008·American Journal of Epidemiology·Kathy J Helzlsouer
Mar 8, 2016·Cancer·Sophia C KamranAkila N Viswanathan
Sep 19, 2008·Cancer·Melissa L BondyBrain Tumor Epidemiology Consortium
Aug 25, 2015·The Laryngoscope·Howard W FrancisDavid W Eisele
Oct 11, 2016·Neurologic Clinics·Katharine A McNeill
Oct 5, 2017·Journal of Public Health·Hajar SadeghiYazdan Shabani
Aug 23, 2002·Epidemiology·Cécile M RonckersCharles E Land
Sep 25, 2020·Acta Oncologica·Katharina EibenbergerMartin Zehetmayer
Jun 27, 2013·Human & Experimental Toxicology·Edward J Calabrese, Gaurav Dhawan
May 26, 2017·The Laryngoscope·Robert J Ruben
Aug 2, 2020·Antimicrobial Resistance and Infection Control·B van DijkB C H van der Wal
Sep 24, 2020·Dose-response : a Publication of International Hormesis Society·Paul A OakleyDeed E Harrison
Sep 10, 2019·Dose-response : a Publication of International Hormesis Society·Gaurav DhawanEdward J Calabrese
Oct 1, 2020·Dose-response : a Publication of International Hormesis Society·Paul A Oakley, Deed E Harrison

Related Concepts

Adenoidal Structure
Malignant Neoplasms
Pituitary Hormones
Radiotherapy, Targeted
Gonadal Steroid Hormones
Thyroid Gland Follicular Adenoma

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.