Abstract
There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. Consequently, the International Agency for Research on Cancer (IARC) has evaluated cobalt metal without tungsten carbide as possibly carcinogenic to humans (Group 2B). The aim of the study was to assess the risk of cancer among workers employed in a Finnish cobalt plant since the beginning of production in 1968. The study cohort consisted of all males employed by the Finnish cobalt plant for at least a year during 1968-2004. The follow-up for cancer was performed by studying the files of the Finnish Cancer Registry, using personal identity codes as a key. The cohort was divided into subcohorts by exposure levels. Standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) were calculated as ratios of the observed numbers of cancer cases and the numbers expected on the basis of incidence rates in the population of the same region. The follow-up cohort consisted of 995 men with 26,083 person-years. During the follow-up period, 92 cases of cancer were diagnosed (SIR 1.00, 95% CI 0.81-1.22), six of which were lung cancer cases (SIR 0.50; 95% CI 0.18-1.08). The only cancer type with increased incidence was tongue cancer (th...Continue Reading
References
Nov 1, 1986·Cancer·P A SchulteW Stringer
Jan 1, 1987·American Journal of Industrial Medicine·J M MurJ Lafitte
Nov 1, 1994·American Journal of Industrial Medicine·G LasfarguesJ Moline
Jan 1, 1994·Acta Oncologica·L TeppoM Lehtonen
Aug 5, 1998·American Journal of Epidemiology·J J MoulinA Perdrix
Jun 15, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·J R BucherB J Chou
Sep 14, 2001·Occupational and Environmental Medicine·D LisonM Kirsch-Volders
Dec 18, 2001·British Journal of Cancer·V BagnardiG Corrao
Jul 23, 2003·American Journal of Industrial Medicine·Asko LinnaJukka Uitti
Oct 13, 2004·Occupational and Environmental Medicine·A LinnaJ Uitti
Feb 11, 2005·Epidemiology·Tom K GrimsrudAage Andersen
Dec 31, 2005·EXS·Troy R Durham, Elizabeth T Snow
Jan 6, 2006·IUBMB Life·David BernhardGeorg Wick
Oct 16, 2010·Methods in Molecular Biology·Eero Pukkala
Jul 8, 2015·European Urology·Marcus G CumberbatchCarlo La Vecchia
Oct 18, 2016·American Journal of Industrial Medicine·Markku PavelaEero Pukkala
Citations
Dec 8, 2017·Journal of Occupational and Environmental Medicine·Gary M MarshJohn W Cherrie
May 24, 2018·Nanotoxicology·Francesca CappelliniHanna L Karlsson
Sep 12, 2018·Critical Reviews in Toxicology·D LisonG Van Maele-Fabry
Mar 5, 2018·Biological Trace Element Research·Anla HuQihong Zhao
Oct 10, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Natalie H MatthewsEunyoung Cho
Sep 9, 2020·Environmental Toxicology and Pharmacology·Ademola Adetokunbo OyagbemiAdeolu Alex Adedapo
Apr 17, 2021·BMC Cancer·Behzad KianiBenyamin Hoseini
May 21, 2021·Environmental Science and Pollution Research International·Abhishek Sharan, Seema Nara
Jun 14, 2021·Ecotoxicology and Environmental Safety·Jian-Jie GaoQuan-Hong Yao
Jul 7, 2021·Regulatory Toxicology and Pharmacology : RTP·Shumin ZhangPaul M Coplan