Cancer incidence in a cohort of Finnish male smokers

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Nea MalilaE Pukkala

Abstract

A total of 29,133 male smokers, aged 50-69 years, were recruited into the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in 1984-1988. The nationwide Finnish Cancer Registry (FCR) recorded 5944 incident cases of cancer in this cohort through the end of 1999. Compared with the FCR data of the entire Finnish male population of same age the standardized incidence ratio (SIR) of total cancer in the ATBC cohort was 1.55 [95% confidence interval (CI) 1.51-1.59]. There was a significant excess of established smoking-related malignancies, such as lung cancer (SIR 2.45, 95% CI 2.35-2.56), and cancers of the tongue, mouth, pharynx, larynx, oesophagus, pancreas, stomach, liver, urinary bladder and kidney. In addition to these sites, cancers of the prostate and colon were slightly more common in the ATBC cohort than in the total Finnish male population (SIR 1.10, 95% CI 1.04-1.18 and SIR 1.14, 95% CI 1.00-1.30, respectively). In conclusion, the risk of many cancers was significantly higher in the ATBC Study cohort compared with the total Finnish male population of same age. In addition to the well known smoking-related cancers, cigarette smoking may increase slightly the risk of colon and prostate cancer, too.

References

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Citations

Apr 26, 2012·Der Urologe. Ausg. A·B J Schmitz-DrägerUNKNOWN Mitglieder des Arbeitskreises Prävention, Umwelt und Komplementärmedizin (PUK) der Deutschen Gesellschaft für Urologie e. V.
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nora L NockBenjamin A Rybicki
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleMarie-Elise Parent
Aug 21, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·László HerszényiFabio Farinati
Oct 23, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·László HerszényiZsolt Tulassay
Oct 3, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·R Klos, M C Thorne
Oct 18, 2013·Scandinavian Journal of Gastroenterology·Airi JussilaMartti A Färkkilä

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