PMID: 11915436Mar 28, 2002Paper

Cancer incidence in persons with Down syndrome in Israel

Down's Syndrome, Research and Practice : the Journal of the Sarah Duffen Centre
L K Boker, J Merrick

Abstract

The purpose of this study was to assess the incidence rates of leukaemia and other malignancies in persons with Down syndrome in Israel. The target population consisted of all persons with Down syndrome in the period of 1948-1995 and the study population was divided into two subgroups: (1) Persons born in Israel between 1979-95 (registry group) and (2) Persons currently or past-institutionalised, born before 1979 (institution group). The study population was linked to the Cancer Registry and cases that had been diagnosed through December 1995 were subsequently identified. The observed incidence rates were compared to expected rates in the general population. Standardised Incidence Ratios (SIR) and 95% confidence intervals were computed for each disease category. Analyses of results were performed separately for each subgroup of our study population. In the registry group seven cancer cases were observed as compared to 1.5 expected (SIR = 4.67 95% CI 1.9-9.6), all of which were leukaemia cases. For the institution group a total of 17 cancer cases were observed compared to 12.8 expected. These included four cases of leukaemia (SIR = 6.90 95% CI 1.9-17.7). An excess of gastric cancer in males, based on two cases (SIR = 11.9 95% CI...Continue Reading

Citations

Sep 30, 2006·Digestive Diseases and Sciences·Daniel SatgéJean-François Fléjou
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D SatgéM-O Réthoré
Jun 25, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroaki EharaHisao Ito
Dec 8, 2015·IEEE Transactions on Affective Computing·Zakia HammalDaniel S Messinger
Nov 1, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Henrik HasleSonja A Rasmussen
Dec 6, 2011·Research in Developmental Disabilities·Ariel TenenbaumJoav Merrick
Nov 12, 2014·Frontiers in Public Health·Joav MerrickEli Carmeli
Oct 19, 2005·International Journal of Cancer. Journal International Du Cancer·Kristiina PatjaMarkus Kaski
Apr 18, 2007·International Journal of Cancer. Journal International Du Cancer·Eduardo De StefaniMaría Mendilaharsu

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