Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Kalyan PandeDrake M LaFace

Abstract

Intravascular delivery (1.5 x 10(9) particles and higher) of recombinant adenovirus (rAd) induces myeloid cell mediated, self-limiting hemodynamic responses in normal mice. However, we observed anaphylactoid-type reactions and exacerbated hemodynamic events following rAd injection in mice bearing malignant 4T1 mammary carcinoma. Because 4T1 tumors induce significant CD11b(+)Gr-1(+) myeloid cell expansion and activation, we set to determine whether this causes rAd-induced exaggerated responses. When treated with a single intravenous dose (1 x 10(10) particles) of rAd, mice implanted with 4T1 carcinoma succumbed due to the anaphylactoid-type reactions. In contrast, normal mice and mice implanted with a related mammary carcinoma (66cl4) that does not induce CD11b(+)Gr-1(+) cell expansion, showed minimal responses. Depletion of phagocytic CD11b(+)Gr-1(+) cells prior to rAd delivery protected 4T1 tumor-bearing animals, whereas passive transfer of CD11b(+)Gr-1(+) cells from 4T1 tumor-bearing animals was sufficient to convey susceptibility to anaphylactoid-type reactions in normal animals. We further show that there is upregulation of nitric oxide and leukotriene signaling pathways in the 4T1 tumor-induced CD11b(+)Gr-1(+) myeloid cell...Continue Reading

References

Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Jan 29, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard E MorrisseyJames S MacDonald
Jul 12, 2002·Cancer Immunology, Immunotherapy : CII·Sergei Kusmartsev, Dmitry I Gabrilovich
Dec 26, 2002·Annual Review of Immunology·Hannah J GouldLyn Smurthwaite
Jan 11, 2003·Cancer Gene Therapy·Tony ReidDavid Kirn
Jun 15, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jeffrey S SmithAndrew P Byrnes
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
May 4, 2005·The Journal of Allergy and Clinical Immunology·Bruce S Bochner, William W Busse
May 7, 2005·Cancer Immunology, Immunotherapy : CII·Pratima SinhaSuzanne Ostrand-Rosenberg
Jul 27, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Todd MachemerDrake LaFace
Sep 13, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frédérique Maindrault-GoebelAimery De Gramont
Apr 7, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kathrin SchererAndreas J Bircher
Jul 11, 2006·Current Opinion in Allergy and Clinical Immunology·Mariana Castells
Oct 4, 2006·The Journal of Clinical Investigation·Giovanna GallinaVincenzo Bronte
Sep 4, 2007·The Journal of Allergy and Clinical Immunology·Fred D Finkelman
Dec 8, 2007·Nature·Farbod ShojaeiNapoleone Ferrara

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Citations

Dec 3, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhili XuAndrew P Byrnes
Nov 19, 2010·Molecular Medicine·Alex G CuencaLyle L Moldawer
Feb 15, 2011·International Immunopharmacology·Drake LaFace, James Talmadge
Sep 13, 2011·Cancer Cell·Zvi GranotRobert Benezra
May 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alex G CuencaLyle L Moldawer
Feb 16, 2018·Nature Communications·Matteo MassaraRaffaella Bonecchi
Nov 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melisa J HamiltonKevin L Bennewith
Mar 13, 2014·The Journal of Biological Chemistry·Sangkyung EomDooil Jeoung

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