Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers

Biomolecules & Therapeutics
Soo-Youl Kim

Abstract

Drug development groups are close to discovering another pot of gold-a therapeutic target-similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular biology has improved cancer therapy through the identification of more pharmaceutically viable targets, and yet major problems and risks associated with late-phase cancer therapy remain. Presently, a growing number of reports have initiated a discussion about the benefits of metabolic regulation in cancers. The Warburg effect, a great discovery approximately 70 years ago, addresses the "universality" of cancer characteristics. For instance, most cancer cells prefer aerobic glycolysis instead of mitochondrial respiration. Recently, cancer metabolism has been explained not only by metabolites but also through modern molecular and chemical biological techniques. Scientists are seeking context-dependent universality among cancer types according to metabolic and enzymatic pathway signatures. This review presents current cancer metabolism studies and discusses future directions in cancer therapy targeting bio-energetics, bio-anabolism, and autophagy, emphasizing the important contribution of cancer metabolism in cancer therapy.

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Citations

Feb 4, 2016·Advances in Biological Regulation·Renee C Geck, Alex Toker
Apr 25, 2016·Biochemical and Biophysical Research Communications·Moemi KawaguchiKousei Ito
Jun 25, 2016·Biochemical and Biophysical Research Communications·Jae-Seon LeeSoo-Youl Kim
Apr 23, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Na-Na LuJing Gao
Jan 19, 2019·Archives of Pharmacal Research·Soo-Youl Kim
Dec 8, 2017·Biomolecules & Therapeutics·Soo-Youl Kim
Nov 7, 2019·Cancers·Mi Kyung Park, Chang Hoon Lee
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Keun-Yeong Jeong

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Methods Mentioned

BETA
xenograft
environmental stress

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