Cancer metabolomic markers in urine: evidence, techniques and recommendations

Nature Reviews. Urology
Sarah S DingesLeo L Cheng

Abstract

Urinary tests have been used as noninvasive, cost-effective tools for screening, diagnosis and monitoring of diseases since ancient times. As we progress through the 21st century, modern analytical platforms have enabled effective measurement of metabolites, with promising results for both a deeper understanding of cancer pathophysiology and, ultimately, clinical translation. The first study to measure metabolomic urinary cancer biomarkers using NMR and mass spectrometry (MS) was published in 2006 and, since then, these techniques have been used to detect cancers of the urological system (kidney, prostate and bladder) and nonurological tumours including those of the breast, ovary, lung, liver, gastrointestinal tract, pancreas, bone and blood. This growing field warrants an assessment of the current status of research developments and recommendations to help systematize future research.

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Jun 12, 2020·Diagnostics·Kit Man ChanMelanie MacGregor
Oct 1, 2020·Cancers·Jiawei LiDong-Xu Liu
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Methods Mentioned

BETA
NMR
environmental stress
urine
electrophoresis
metabolomic profiling
biopsies
PCA
biopsy
metabolomic
urine collections

Clinical Trials Mentioned

NCT02955173
NCT02781272
NCT03585114
NCT03047616
NCT03091491
NCT03727009
NCT01574677
NCT01511653

Related Concepts

Biological Markers
Urinary Bladder
Blood
Breast
Malignant Neoplasms
Kidney
Laboratory Procedures
Liver
Lung
Neoplasms

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