PMID: 9540288Apr 16, 1998Paper

Cancer metastasis: biological and clinical aspects

Irish Journal of Medical Science
M J Duffy

Abstract

The main cause of morbidity and mortality in cancer is the formation of distant metastases. While alterations in c-oncogenes, tumour suppressor genes and DNA repair enzymes are the key molecules involved in carcinogenesis, increased expression of proteases, motility factors and altered expression of adhesion molecules are causally involved in metastasis. The proteases mediating metastasis include urokinase plasminogen activator, cathepsin B, D and L and various matrix metalloproteinases. Certain proteases involved in metastasis (e.g., urokinase plasminogen activator) have been shown to be strong and independent prognostic markers for a variety of cancers. Finally, molecules involved in cancer spread are potential targets for new forms of anti-metastatic therapies.

References

May 1, 1992·Clinical & Experimental Metastasis·M J Duffy
Dec 1, 1990·Cancer Metastasis Reviews·B F SloaneJ Rozhin
Dec 16, 1993·Nature·E L BergE C Butcher
Jun 6, 1996·The New England Journal of Medicine·P S Frenette, D D Wagner
Jun 1, 1996·Nature Medicine·M S O'ReillyJ Folkman
May 1, 1996·The British Journal of Surgery·M D Menger, B Vollmar
Jan 1, 1996·Advances in Clinical Chemistry·M J Duffy
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·P A AndreasenM J Duffy

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Citations

May 20, 2003·International Journal of Surgical Pathology·Constantina PetrakiFlora Sotsiou
Aug 5, 2000·The American Journal of Gastroenterology·D MaguireF Shanahan
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S. O'TooleJ. Bonnar
May 8, 2009·Nanotechnology·A V Vakhrushev, M V Suyetin

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