Cancer mortality after radiotherapy for a skin hemangioma during childhood

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Marie-Gabrielle DondonFrançois Eschwege

Abstract

A cohort study was performed as part of a European Radiation Protection Program to investigate the carcinogenic effect of treatment with ionizing radiation in early childhood. This paper presents mortality after radiotherapy in this cohort. The cohort comprised 7037 patients under 15 years of age treated for a skin hemangioma between 1940 and 1973 at the Institut Gustave-Roussy, among whom 4940 received radiotherapy. The vital status and causes of death were obtained as well as the mortality rates in the general French population. External and internal analyses were performed. Standardized mortality ratio (SMR) and relative risk (RR) variations according to exposure to radiotherapy or not and the type of treatment were studied. During the 1969-1997 follow-up period, 16 cohort patients died of cancer, 14 after radiotherapy. A non-significant excess of cancer-related mortality was observed for irradiated patients as compared to the general population (SMR=1.53; 95% CI=0.86-2.48). Treatment with (226)Ra seemed to play a significant role (RR=2.53; 95% CI=0.84-7.07) compared to no radiotherapy. This study suggests an excess risk of cancer-related mortality in patients treated during early childhood with radiotherapy for skin hemangi...Continue Reading

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Citations

Jun 3, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Elliot WeissRoy G Geronemus
Jul 8, 2010·Cancer Causes & Control : CCC·Nadia HaddyFlorent de Vathaire
May 17, 2015·Medical Physics·C Candela-JuanÅ Carlsson Tedgren
Aug 28, 2010·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Lamya YousifHajo Zeeb
Jul 14, 2005·Current Opinion in Pediatrics·Francine Blei
Jan 9, 2013·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Richard Wakeford
Nov 16, 2011·Melanoma Research·Nadia HaddyFlorent de Vathaire
Apr 24, 2019·Oral and Maxillofacial Surgery·Birte Julia Siegmund, Jan Rustemeyer
Nov 14, 2020·Clinical and Experimental Dermatology·M J LaveryJ Crema

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