PMID: 8952217Sep 1, 1996Paper

Cancer mortality in Minamata disease patients exposed to methylmercury through fish diet

Journal of Epidemiology
Y KinjoH Kato

Abstract

We report here a historical cohort study on cancer mortality among Minamata disease (MD) patients (n = 1,351) in Kagoshima and Kumamoto Prefectures of Japan. Taking into account their living area, sex, age and fish eating habits, the residents (n = 5,667; 40 years of age or over at 1966) living in coastal areas of Kagoshima, who consumed fish daily, were selected as a reference group from the six-prefecture cohort study conducted by Hirayama et al. The observation periods of the MD patients and of the reference group were from 1973 to 1984 and from 1970 to 1981, respectively. Survival analysis using the Poisson regression model was applied for comparison of mortality between the MD patients and the reference group. No excess of relative risk (RR) adjusted for attained age, sex and follow-up period was observed for mortality from all causes, all cancers, and non-cancers combined. Analysis of site-specific cancers showed a statistically significant decrease in mortality from stomach cancer among MD patients (RR, 0.49; 95% confidence interval, 0.26-0.94). In addition, a statistically significant eight-fold excess risk, based on 5 observed deaths, was noted for mortality from leukemia (RR, 8.35; 95 % confidence interval 1.61-43.3)....Continue Reading

Citations

Mar 16, 2007·International Archives of Occupational and Environmental Health·Takashi YorifujiNorito Kawakami
Sep 1, 2002·Environmental Toxicology and Pharmacology·M Christopher Newland
Apr 20, 2014·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Kevin M RiceEric R Blough
Oct 1, 2015·Biological Trace Element Research·Hye-Kyung ChungKyung Rae Kim
Mar 13, 2003·The Tohoku Journal of Experimental Medicine·Tomoko OkaMakoto Futatsuka
Jan 17, 2020·American Journal of Hematology·Maro OhanianCharles Dumontet
Dec 23, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert R SokalBarbara A Thomson
Jul 28, 2019·Scientific Reports·Jordan H CreedKathleen M Egan
Dec 21, 2019·Archives of Environmental Contamination and Toxicology·Brenda Natasha Souza CostaMarcelo de Oliveira Lima
Jun 21, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Natalie H MatthewsEunyoung Cho

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