Cancer pain relieved by long-term epidural morphine with permanent indwelling systems for self-administration

Journal of Neurosurgery
C PolettiN T Zervas

Abstract

Clinical trials for abatement of intractable pelvic cancer pain were conducted in two patients, each electing surgical implantation of one of two indwelling catheter systems for administration of morphine into the spinal epidural space. Both systems, one consisting of a partially indwelling Broviac catheter, and the other, completely indwelling, consisting of a morphine reservoir connected to a shunt pump and on-off Hakim valve assembly, permitted the patients to return home where they could self-administer epidural morphine. Each patient reported that 2 mg of epidural morphine provided 8 to 12 hours of pain relief at a level of superior to their previous narcotic medication. On a regimen of 2 mg of epidural morphine administered twice daily, both patients experienced analgesia for 6 months, unaccompanied by alterations in sensory, motor, or cognitive functioning, and with a little drug tolerance reaction.

References

Mar 10, 1979·Lancet·M BeharJ T Davidson
Jun 30, 1979·Lancet·D B Scott, J McClure
Feb 1, 1979·Anesthesiology·J K WangJ E Thomas
Jun 25, 1976·Science·T L Yaksh, T A Rudy
Dec 1, 1974·Canadian Journal of Physiology and Pharmacology·O CalvilloR S Neuman
Jul 1, 1980·Anesthesia and Analgesia·P R BromageD Chestnut
Mar 1, 1980·Archives of Surgery·J L Ponsky, M W Gauderer
Dec 1, 1980·American Journal of Surgery·J H ThomasA S Hermreck
Oct 1, 1980·Anesthesiology·M S ChayenA Borvine
Feb 1, 1980·Archives of Surgery·M R HurtubiseK B McCredie
Feb 1, 1980·Anaesthesia·J L GrahamW McCaughey
May 16, 1980·European Journal of Pharmacology·T L Yaksh, R P Elde
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

❮ Previous
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Citations

Nov 1, 1995·Journal of Neuro-oncology·S Bakhshi, R B North
Jan 1, 1984·Acta neurochirurgica·J J MooijJ W Beks
Sep 1, 1982·World Journal of Surgery·R C HickeyB Borgelt
Mar 1, 1985·Klinische Wochenschrift·M ZenzM Tryba
Jul 23, 1987·European Journal of Pharmacology·C Advokat, P Burton
Jan 1, 1987·Physiology & Behavior·C AdvokatC B Tyler
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·C Advokat
Oct 1, 1995·Journal of Pain and Symptom Management·S J HassenbuschD S Guthrey
Dec 31, 1997·Journal of Pain and Symptom Management·J A Aldrete, S L Giles
Jul 11, 1985·The New England Journal of Medicine·K M Foley
Jun 1, 1982·Journal of Neurosurgery·R E HarbaughM Pageau
Oct 1, 1983·Journal of Neurosurgery·R D LobatoE Lamas
Aug 1, 1987·Journal of Neurosurgery·R D Penn, J A Paice
Jan 1, 1988·The International Journal of Neuroscience·R P IaconoC R Bamford
May 1, 1985·Seminars in Oncology Nursing·R B Catalano
Jan 1, 1986·Journal of Pain and Symptom Management·S D WaldmanM L Allen
Jun 21, 2005·European Journal of Pain : EJP·Vincent J MieleJulian E Bailes
Jan 1, 1984·General Hospital Psychiatry·B J Urban
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·S ArnérL L Gustafsson
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·A Vainio, I Tigerstedt
Jan 1, 1987·Acta Anaesthesiologica Scandinavica. Supplementum·V VentafriddaF De Conno
Jan 1, 1985·Acta Anaesthesiologica Scandinavica·S Arnér, B Arnér
Nov 30, 2006·Pain Practice : the Official Journal of World Institute of Pain·L LouC L King
Jun 1, 1989·Cancer·T Ferrer-Brechner
Jun 1, 1989·Cancer·N SundaresanJ E Hughes
Dec 1, 1984·Cancer·C S Cleeland
Jan 1, 1988·Annals of the New York Academy of Sciences·G Koning, F Feith
Nov 24, 2005·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Anna Du Pen
Oct 29, 2013·The Cochrane Database of Systematic Reviews·Jane C BallantyneGanesan Baranidharan
May 1, 1985·Journal of Surgical Oncology·T Yablonski-PeretzR Catane
Jun 1, 1990·Journal of Pain and Symptom Management·G TurnageL Wild

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Next ❯

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