Cancer prevention and treatment using combination therapy with natural compounds.

Expert Review of Clinical Pharmacology
Edward R Sauter

Abstract

Introduction: Naturally occurring compounds play an essential role in the prevention and treatment of various cancers. There are more than 100 plant and animal based natural compounds currently in clinical use.Areas covered: 1) The importance of natural products combinations in the prevention and treatment of cancer, 2) the need to maximize efficacy while minimizing side effects when using natural product combinations, and 3) specifics related to plant and animal derived natural products, as well as agents derived from natural products. Therapies using natural compounds that have been investigated, their rationale, mechanism of action and findings are reviewed. When the data warrant it, combined interventions that appear to increase efficacy (compared with monotherapy) while minimizing toxicity have been highlighted. Pubmed was used to search for relevant publications.Expert opinion: Combination therapy with natural compounds has the potential to be more effective than single agent therapy. Similar to pharmacologic agents, the goal is to maximize efficacy while mimimizing potential side effects. There is an increasing research focus on the development of agents derived from natural products, with notable successes already achie...Continue Reading

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Citations

Jul 21, 2020·Molecular Biology Reports·Arash Ghorbani-Abdi-SaedabadReyhane Hoshyar
Jan 11, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yogeswari SubramaniamJayabaskaran Chelliah
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Celso AlvesRui Pedrosa
Jun 19, 2021·Natural Product Research·Luciana Bitencourt de SouzaAna Lucia Tasca Gois Ruiz
Aug 8, 2021·Cancers·Oumaima JaouadiFatma Ben Aissa-Fennira
Aug 10, 2021·World Journal of Clinical Oncology·Zaynab FatfatHala Gali-Muhtasib

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