Cancer prevention studies: past, present, and future directions

Nutrition
K N PrasadP Hovland

Abstract

In spite of extensive research on vitamins and diet, a consistent beneficial role of vitamin supplements, together with diet modification in human cancer prevention, has not been demonstrated. Published results of human intervention trials with vitamin supplements have been contradictory. This review critically, but briefly, evaluates (a) current concepts of human carcinogenesis, (b) effects of vitamins on biochemical parameters that are pertinent to cancer prevention, and (c) whether past or current protocols for intervention trials among high-risk populations adopt specific scientific rationales that are based on laboratory and human epidemiology studies. In addition, we propose a novel experimental design for intervention trials among high-risk human populations that is based on sound scientific principles derived from laboratory and human epidemiologic data on vitamins, diet, lifestyle, and cancer prevention. Such trials would answer a fundamental public health issue of today: Does supplementation with multiple vitamins, together with diet and lifestyle modifications, reduce the risk of cancer?

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Citations

Jul 13, 2004·Cancer Chemotherapy and Pharmacology·Jiuhong KangYingxian Ou
Nov 25, 2003·The Journal of Nutritional Biochemistry·Annette LienauKlaus Albert
Mar 22, 2003·Gynecologic Oncology·Jeanne A DriskoVerda J Hunter
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Katharine Milton
Jan 21, 2012·Journal of Agricultural and Food Chemistry·Chih-Min YangMiao-Lin Hu
Feb 1, 2014·BMC Complementary and Alternative Medicine·Elisângela DüsmanVeronica Elisa Pimenta Vicentini
Apr 24, 2002·Best Practice & Research. Clinical Gastroenterology·Nachum Vaisman, Nadir Arber
Nov 16, 2004·Leukemia Research·Maria PapageorgiouMaria Kalmanti
Aug 31, 1999·The Proceedings of the Nutrition Society·W P James, A Ralph
Sep 25, 2001·Experimental Biology and Medicine·K N PrasadK C Prasad
May 15, 2004·Nutrition Reviews·Martin A WhitesideGary L Johanning

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