Cancer Registry follow-up for 17 million person-years of a nationwide maternity cohort

Cancer Medicine
Matti LehtinenJoakim Dillner

Abstract

Population-based Finnish Maternity Cohort (FMC) comprises 2M first trimester sera collected from 1M women during 33 years. Informed consent is by the opt-out principle, and linkages with cancer and population registries provide a base for over time and over generation studies. Follow-up for 17M person-years by the end of 2014 can identify 39,700 cases of invasive cancer and 18,900 cases of premalignant breast and cervix lesions, and basal cell carcinoma diagnosed after serum sampling. For women with multiple pregnancies, serial samples taken before cancer diagnosis are available. Offspring of the women have developed more than 4000 cancers. For 100,000 individuals, samples taken during the pregnancies of both their mothers and grandmothers enable familial cancer studies. FMC continues to collect samples, and surveillance of exposures or interventions like vaccination programs is feasible. In summary, the FMC is a unique, accessible biobank for epidemiological, biomarker, and surveillance studies on cancer.

References

Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·P KoskelaJ Paavonen
Jan 10, 2001·JAMA : the Journal of the American Medical Association·T AnttilaJ Paavonen
Apr 12, 2001·The New England Journal of Medicine·J MorkJ Dillner
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Matti LehtinenJoakim Dillner
Jul 29, 2003·American Journal of Epidemiology·Matti LehtinenTuula Lehtinen
Dec 17, 2008·American Journal of Epidemiology·Aline Simen KapeuMatti Lehtinen
Mar 26, 2013·International Journal of Cancer. Journal International Du Cancer·Tapio LuostarinenMatti Lehtinen
Jun 6, 2013·Nature Reviews. Clinical Oncology·Matti Lehtinen, Joakim Dillner

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Citations

Jan 25, 2019·Molecular Oncology·Joakim Dillner
Dec 20, 2019·BMC Medical Research Methodology·Jasper FreseArndt-Peter Schulz

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