Cancer Research UK Centre for Drug Development: translating 21st-century science into the cancer medicines of tomorrow

Drug Discovery Today
James W A Ritchie, Robert J Williams

Abstract

The Cancer Research UK Centre (CRUK) for Drug Development (CDD) can trace its origins back to the Cancer Research Campaign Phase I/II Committee (created in 1980) and to date has tested over 120 potential cancer medicines in early-phase clinical trials. Five drugs are now registered, providing benefit to thousands of patients with cancer as part of their routine standard of care. In recent years, the CDD has established several different business and operating models that provide it with access to the pipelines of pharmaceutical and biotechnology companies. This has enabled potential new treatments to be taken into clinical development that might have otherwise languished on companies' shelves and has increased the number of drug combinations being explored in early-phase clinical trials.

References

Jul 8, 1998·Cancer Chemotherapy and Pharmacology·P BealeI Judson
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard W SeymourUNKNOWN Cancer Research Campaign Phase I/II Clinical Trials committee
Jun 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gordon J S RustinPatricia M Price
Jun 8, 2004·Current Cancer Drug Targets·Veronique Guillemard, H Uri Saragovi
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Udai BanerjiIan Judson
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susannah J StanwayR Charles Coombes
Aug 28, 2007·International Journal of Nanomedicine·Stewart D ChipmanJack W Singer
Nov 15, 2008·Nature Reviews. Drug Discovery·Ian Walker, Herbie Newell
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah A LowndesAdrian L Harris
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ruth PlummerHilary Calvert
Feb 18, 2009·Cancer Immunology, Immunotherapy : CII·Eyad ElkordPeter L Stern
Feb 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emma DeanMalcolm Ranson
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel HochhauserDuncan Jodrell
May 9, 2009·International Journal of Oncology·Leonard W SeymourJames Cassidy
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tim MeyerRichard H Begent
Jun 11, 2010·Nature Reviews. Cancer·Timothy A YapJohann S de Bono
Jul 16, 2010·Science Translational Medicine·Mark R MiddletonDavid J Kerr
Oct 30, 2010·Nature Reviews. Drug Discovery·Shivanni KummarJames H Doroshow
Feb 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simon PaceyIan Judson
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 8, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J DansonM Ranson
Jan 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan M PattersonGordon J S Rustin
Mar 24, 2012·Molecular Oncology·Swen HoelderPaul Workman
Oct 22, 2013·Cancer Chemotherapy and Pharmacology·Laura HorsleyUNKNOWN Cancer Research UK Drug Development Office Phase I clinical trial
May 2, 2014·Nature Reviews. Drug Discovery·Asher Mullard

❮ Previous
Next ❯

Citations

Aug 8, 2015·Inorganic Chemistry·Rajathees RajaratnamEric Meggers
Aug 25, 2019·Marine Drugs·Shaden A M KhalifaHesham R El-Seedi
Dec 21, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Ághata Cardoso da Silva RibeiroAntonio Távora de Albuquerque Silva
Nov 26, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thomas F Whayne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.