Cancer resistance, high molecular weight hyaluronic acid, and longevity

Journal of Cell Communication and Signaling
Gary J Fisher

Abstract

Longevity varies greatly among mammals. The naked mole rat is among the longest-lived rodents, having an average lifespan of 32 years, compared to the similarly-sized house mouse with lifespan of 4 years. The rate of cancer also varies widely among mammals and interestingly, the naked mole rat is essentially cancer-free (Gorbunova et al., Nat Rev Genet 15(531):540, 2014). A series of elegant studies (Tian et al. Nature 499:346-349, 2013) has revealed that this cancer resistance derives from the abundant production of high molecular weight hyaluronic acid. Remarkably, high molecular weight hyaluronic acid, which accumulates within the extracellular matrix, stimulates an intracellular pathway that induces expression of p16(ink4a) and suppresses oncogenic transformation.

References

Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andrei SeluanovVera Gorbunova
Jul 2, 2014·Nature Reviews. Genetics·Vera GorbunovaJan Vijg

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Citations

Sep 12, 2015·Journal of Cell Communication and Signaling·Bernard Perbal
Apr 16, 2016·Soft Matter·Kenneth S Rankin, Daniel Frankel
May 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kyle R TaylorCarlos E Rodriguez
May 31, 2016·Gut Pathogens·Tewodros DebebeGerd Birkenmeier
Mar 24, 2016·Veterinary Pathology·A Piersigilli, D K Meyerholz
May 3, 2019·Immunogenetics·Mónica Lopes-MarquesL Filipe C Castro
Feb 7, 2019·The FEBS Journal·Anastasia G TavianatouNikos K Karamanos
Sep 15, 2016·Journal of Experimental Neuroscience·Thiago Fernando BeckhauserRoberto De Pasquale
Feb 17, 2019·Theory in Biosciences = Theorie in Den Biowissenschaften·Anastasio Salazar-Bañuelos
Jun 6, 2018·Frontiers in Cell and Developmental Biology·James B McCarthyEva A Turley
Oct 25, 2017·Frontiers in Oncology·Lena BohaumilitzkyHeike Boehm

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