Cancer screening activity results in overdiagnosis and overtreatment of papillary thyroid cancer: A 10-year experience at a single institution

PloS One
Krzysztof KaliszewskiJerzy Rudnicki

Abstract

It is estimated that one of the potential cause of the increasing prevalence of thyroid cancer (TC) is the easier and widespread access to diagnostic tools. If an individual evaluates the thyroid gland due to a mentioned mechanism without considering TC risk factors or symptoms, we can describe this phenomenon as cancer screening activity (CSA). We 1) estimated what types of TC were diagnosed due to CSA, 2) analyzed what clinicopathological features were characteristic of TCs diagnosed by CSA, 3) determined if these features were characteristic of indolent cases, and finally we 4) assessed whether CSA could have resulted in the increasing incidence of potentially indolent papillary thyroid cancer (PTC). A retrospective review of 4,701 medical records of patients admitted and surgically treated at one surgical center between 2008 and 2017 was performed. Among the enrolled patients, 569 (12.1%) had thyroid malignancy, and 514 (10.9%) were diagnosed with PTC. We divided these patients into two groups: 1) patients in whom TC diagnostics were performed without considering any TC risk factors or symptoms (CSA-yes) and 2) those in whom TC was diagnosed due to TC risk factors or symptoms (CSA-no). We then compared the clinicopathologic...Continue Reading

References

Sep 22, 1998·Acta Oncologica·P Hall, L E Holm
Nov 26, 2008·Archives of Internal Medicine·Per-Henrik ZahlH Gilbert Welch
Apr 24, 2010·Journal of the National Cancer Institute·H Gilbert Welch, William C Black
Nov 26, 2010·The Laryngoscope·Louise DaviesH Gilbert Welch
May 11, 2013·BMJ : British Medical Journal·Paul D P PharoahNora Pashayan
Jun 6, 2013·The Laryngoscope·Myriam LoyoChristine G Gourin
Jul 31, 2013·JAMA : the Journal of the American Medical Association·Laura J EssermanBrian Reid
Aug 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BosettiC La Vecchia
Aug 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Annick Van den BruelBrigitte Decallonne
Aug 29, 2013·BMJ : British Medical Journal·Juan P BritoVictor M Montori
Sep 7, 2013·Surgery·Jovenel CherenfantRichard A Prinz
Feb 22, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, H Gilbert Welch
Oct 7, 2014·International Journal of Cancer. Journal International Du Cancer·Carlo La VecchiaEva Negri
Feb 11, 2015·Journal of the National Cancer Institute·Pamela M MarcusBarnett S Kramer
Jun 21, 2015·American Journal of Preventive Medicine·Stacy M CarterAlexandra Barratt
Aug 25, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Adele FrancisDaniel Rea
Dec 10, 2015·The New England Journal of Medicine·Hyeong Sik Ahn, H Gilbert Welch
Jul 13, 2016·Journal of Medical Ethics·Stacy M CarterAlexandra Barratt
Jul 28, 2016·The Lancet. Diabetes & Endocrinology·Noboru TakamuraYuri Demidchik
Sep 15, 2016·The New England Journal of Medicine·James A Fagin, Samuel A Wells
Nov 2, 2016·Thyroid : Official Journal of the American Thyroid Association·Hyeong Sik AhnJuan P Brito
Jan 24, 2017·Annals of Internal Medicine·Otis W Brawley
Jun 15, 2017·PloS One·Sabrina JegerlehnerUNKNOWN NICER Working Group
Aug 3, 2017·Public Health Research & Practice·Stacy M Carter, Alexandra Barratt
Jun 12, 2018·International Journal of Endocrinology·Krzysztof KaliszewskiZdzisław Forkasiewicz
Dec 14, 2018·Medicine·Krzysztof KaliszewskiBeata Wojtczak
May 31, 2019·World Journal of Surgical Oncology·Krzysztof KaliszewskiJerzy Rudnicki

❮ Previous
Next ❯

Citations

Jun 3, 2021·Cancers·Klaas Van Den HeedeFausto F Palazzo

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

Statistica
Tibco
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved