Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links.

Seminars in Cancer Biology
Christina Scheel, Robert A Weinberg

Abstract

The epithelial-mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and has been closely associated with the acquisition of aggressive traits by carcinoma cells. EMT programs are orchestrated by a set of pleiotropically acting transcription factors (TFs). The actions of these EMT-TFs enable the early steps of metastasis: local invasion and subsequent dissemination of carcinoma cells to distant sites. However, in most malignancies, the subsequent outgrowth of micrometastatic deposits into macroscopic metastases has the greatest impact on clinical progression. Such metastatic "colonization" reflects the ability of disseminated tumor cells to adapt to a foreign tissue microenvironment. The outgrowth of a metastasis is also thought to be associated with self-renewal, the defining cellular trait of cancer stem cells (CSCs), also termed tumor-initiating cells. Importantly, molecular links between EMT-TFs and self-renewal have emerged, suggesting that EMT programs play critical roles both early and late in the metastatic cascade. The genetic and epigenetic mechanisms that regulate the activation of EMT-TFs and the traits they induce are areas under intensive investigation. Such studies may provide new opport...Continue Reading

References

Sep 15, 1999·Genes & Development·R MaestroG J Hannon
May 25, 2002·Seminars in Cancer Biology·Isaiah J Fidler
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Nov 19, 2003·Mechanisms of Development·David Shook, Ray Keller
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Dec 21, 2004·Cancer Cell·Sandrine Valsesia-WittmannAlain Puisieux
Sep 9, 2005·Nature Reviews. Cancer·Thomas BrabletzThomas Kirchner
Oct 20, 2005·The Biochemical Journal·Ofelia M Martínez-EstradaSenén Vilaró
Oct 31, 2006·Nature Cell Biology·Jong In YookStephen J Weiss
Nov 10, 2006·The EMBO Journal·Agnès BoutetM Angela Nieto
Apr 4, 2007·Molecular and Cellular Biology·Can G PhamGuido Franzoso
Dec 15, 2007·Science·James A KennedyJohn E Dick
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
Jun 4, 2008·Molecular and Cellular Biology·Nicolás HerranzSandra Peiró
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Jun 12, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Emmanuelle Charafe-JauffretMax S Wicha
Jul 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jin Kyung RhoJae Cheol Lee
Jul 19, 2008·Differentiation; Research in Biological Diversity·Rong WangHuang-Tian Yang
Aug 7, 2008·PloS One·Anne-Pierre MorelAlain Puisieux
Nov 26, 2008·The Journal of Pathology·S BrabletzT Brabletz
Jan 30, 2009·The Journal of Investigative Dermatology·Andy J ChienRandall T Moon
Jun 3, 2009·The Journal of Clinical Investigation·Hervé AcloqueM Angela Nieto
Jul 18, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Karen M Downs
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chad J CreightonJenny C Chang
Aug 18, 2009·Biochimica Et Biophysica Acta·Thomas R Geiger, Daniel S Peeper

❮ Previous
Next ❯

Citations

Jan 5, 2014·Experimental Cell Research·Shin MiuraTooru Shimosegawa
Jan 16, 2014·Stem Cell Research & Therapy·Kaori MisunoShen Hu
Dec 18, 2013·Breast Cancer Research and Treatment·Yunhui HuDongsheng Xiong
Aug 15, 2013·Cancer Letters·Sarah ShigdarWei Duan
Aug 29, 2013·Future Oncology·Vincenza ConteducaMichele Aieta
May 7, 2014·Future Oncology·Caroline Coghlin, Graeme I Murray
Apr 2, 2014·Clinical & Experimental Metastasis·Allyson L ValenteRachel E Ellsworth
Aug 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sílvia CufíJavier A Menendez
Aug 6, 2014·Biochemical and Biophysical Research Communications·Aadithya ArumugamMohammad Athar
May 3, 2014·Endocrine-related Cancer·Zhenying GuoRicardo V Lloyd
Nov 5, 2014·Future Medicinal Chemistry·Claire BouvardShoutian Zhu
Nov 23, 2013·Nature Reviews. Cancer·Hira Lal Goel, Arthur M Mercurio
Nov 30, 2013·Breast Cancer Research : BCR·Suzanne A EcclesAlastair M Thompson
May 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hassan FazilatyBabak Behnam
Sep 18, 2012·Der Pathologe·C Röcken, V Warneke
Aug 3, 2013·Der Pathologe·C Röcken
Sep 4, 2013·Genome Medicine·Ellen HeitzerMichael R Speicher
Nov 10, 2013·Nature Medicine·Liling WanYibin Kang
Sep 26, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ian G Macara, Luke McCaffrey
Sep 26, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Johanna I PartanenJuha Klefström
Jan 15, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mousumi MandalJyotirmoy Chatterjee
Apr 25, 2014·Expert Opinion on Therapeutic Targets·Kevin R GinnebaughFazlul H Sarkar
May 27, 2014·International Journal of Molecular Sciences·Mohini SinghSheila K Singh
Jan 15, 2014·Expert Review of Anticancer Therapy·Breann L Yanagisawa, Linda M S Resar
Jan 21, 2015·Expert Opinion on Drug Delivery·Sarandeep Malhi, Xiaochen Gu
Aug 21, 2015·Connective Tissue Research·Jacqueline Banyard, Diane R Bielenberg
May 4, 2016·Current Stem Cell Reports·Efraín A Cermeño, Andrés J García
Apr 8, 2015·International Journal of Oncology·Carolin KubeltJanka Held-Feindt
May 17, 2015·FEBS Letters·Ruben Bill, Gerhard Christofori
Mar 18, 2015·International Journal of Oncology·Seung Wook KimIsaiah J Fidler
Jan 26, 2016·Acta Biomaterialia·Edith LinRatmir Derda
Jan 26, 2016·Pharmacology & Therapeutics·Stephanie KaypeeTapas K Kundu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.