Cancer stem cells and hypoxia-inducible factors (Review)

International Journal of Oncology
Wei-Wei TongYong Liu

Abstract

Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor cells that exhibit properties similar to those of normal stem cells. Oxygen is an important regulator of cellular metabolism; hypoxia-inducible factors (HIFs) mediate metabolic switches in cells in hypoxic environments. Hypoxia clearly has the potential to exert a significant effect on the maintenance and evolution of CSCs. Both HIF‑1α and HIF‑2α may contribute to the regulation of cellular adaptation to hypoxia and resistance to cancer therapies. This review provides an overview of the roles of HIFs in CSCs. HIF‑1α and HIF‑2α have significant prognostic and predictive value in the clinic and the concept of personalized medicine should be applied in designing clinical trials for HIF inhibitors.

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Citations

May 11, 2019·PloS One·Michael E BregenzerGeeta Mehta
Aug 11, 2020·Frontiers in Cell and Developmental Biology·Christopher Montemagno, Gilles Pagès
Aug 4, 2020·World Journal of Stem Cells·Beatrice AraminiKhawaja Husnain Haider
Apr 5, 2020·Cancers·Juan Manuel MartíFrancisco Javier Oliver
Jul 31, 2020·World Journal of Clinical Oncology·Mónica T FernandesJosé Bragança
Aug 4, 2020·World Journal of Stem Cells·Xuan ZhuZhi-Gang Chen
Feb 13, 2021·Cancers·Rania F ZaarourSalem Chouaib
Apr 4, 2021·Cancers·Leila JahangiriSuzanne D Turner
Jul 25, 2021·Cancers·Julien AncelValérian Dormoy

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