Cancer stem cells and personalized cancer nanomedicine

Nanomedicine
Petra GenerSimo Schwartz

Abstract

Despite the progress in cancer treatment over the past years advanced cancer is still an incurable disease. Special attention is pointed toward cancer stem cell (CSC)-targeted therapies, because this minor cell population is responsible for the treatment resistance, metastatic growth and tumor recurrence. The recently described CSC dynamic phenotype and interconversion model of cancer growth hamper even more the possible success of current cancer treatments in advanced cancer stages. Accordingly, CSCs can be generated through dedifferentiation processes from non-CSCs, in particular, when CSC populations are depleted after treatment. In this context, the use of targeted CSC nanomedicines should be considered as a promising tool to increase CSC sensitivity and efficacy of specific anti-CSC therapies.

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Citations

Feb 27, 2020·Pharmaceutics·Sara MonteroSimo Schwartz
Jul 28, 2019·Biopreservation and Biobanking·Ewa DluskaBarbara Tudek
Nov 9, 2018·Stem Cells International·Petra GenerSimó Schwartz
Dec 2, 2020·Pharmaceutics·Laia Hernandez-OllerSimo Schwartz
Nov 2, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Petra GenerSimo Schwartz
Oct 28, 2021·Advanced Healthcare Materials·Yolanda FernándezMaría J Vicent

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Methods Mentioned

BETA
genetic modification
xenograft
transfection
xenografts
imaging techniques

Clinical Trials Mentioned

ISRCTN40571019
NCT01991938
NCT01277757
NCT01964924
NCT01625286
NCT00955812
NCT01781455
NCT02178956
NCT01830621
NCT02432326

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