PMID: 18421251Apr 19, 2008Paper

Cancer stem cells and survival pathways

Cell Cycle
Dolores HambardzumyanEric C Holland

Abstract

Gliomas and medulloblastomas are the most frequent malignant brain tumors in adult and children respectively. Although both tumors arise in the CNS, there is a significant difference in their therapeutic response. Medulloblastomas are relatively curable, while glioblastomas are basically incurable. During the last decade several reports have demonstrated the existence of cancer stem cells in brain tumors, their location and their response to treatment. We have recently described the therapeutic response of medulloblastomas to radiation in their native microenvironment, illustrating how p53 and Pi3K signaling pathways lead to the evasion of cell death by the nestin-expressing cells in the perivascular stem cell niche, even while the bulk of tumor succumbs to apoptosis.(1) It remains to be determined whether this mechanism of tumor resistance applies to the more complex stem-cell niche and tumor bulk of gliomas.

Citations

Nov 7, 2008·Histochemistry and Cell Biology·Girieca Lorusso, Curzio Rüegg
Mar 5, 2009·Apoptosis : an International Journal on Programmed Cell Death·John Inge JohnsenMarie Arsenian Henriksson
Apr 27, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xiao-qin ZhaoLi-Wu Fu
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tommy AlainNahum Sonenberg
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sarah J ConleyMax S Wicha
Mar 26, 2013·Journal of Ovarian Research·Young Tae ParkHee-Jung An
Oct 21, 2009·The AAPS Journal·Jeffrey T DeSano, Liang Xu
May 17, 2014·World Journal of Gastroenterology : WJG·Kang LiYu-Qiang Nie
Aug 22, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A DubrovskaI Tinhofer
Sep 30, 2009·Current Opinion in Neurology·Ghazaleh Tabatabai, Roger Stupp
Mar 13, 2009·International Journal of Radiation Biology·Raymond E MeynK Kian Ang
Feb 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mengqi YangPeng Huang
Jan 13, 2015·Journal of Neuropathology and Experimental Neurology·Harpreet KaurEric H Raabe
Apr 28, 2012·Cancer Letters·Galina Botchkina
Nov 29, 2011·Radiología·I A Matos RojasM Castillo
Apr 26, 2011·Toxicology and Applied Pharmacology·Kyung-Hwan HyunSu-Jae Lee
Feb 12, 2010·Annals of the New York Academy of Sciences·Prabir RayAnuradha Ray
May 6, 2015·Cancer Science·Jakub Neradil, Renata Veselska
Jul 9, 2013·Molecular Aspects of Medicine·David L SchonbergJeremy N Rich
Jan 25, 2011·Biochimica Et Biophysica Acta·Heather H WardTamara Roitbak
Mar 13, 2014·Molecules and Cells·Rebecca Bish, Christine Vogel
Mar 13, 2014·Cell Stem Cell·Thordur OskarssonJoan Massagué
Jul 2, 2008·Biochemical and Biophysical Research Communications·Renata ZobalovaJiri Neuzil
Jul 17, 2010·Yonsei Medical Journal·Dan Richard LaksHarley Ian Kornblum
May 14, 2016·Cancer Science·Guo-Hao HuangSheng-Qing Lv
Dec 5, 2013·Current Opinion in Allergy and Clinical Immunology·Timothy B OrissAnuradha Ray
Oct 25, 2016·Medicinal Research Reviews·Wei-Lin JinGuan-Zhong Qiu
Apr 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaffer A Ajani
Jul 7, 2009·International Journal of Surgical Pathology·Elisabeth J RushingIren Horkayne-Szakaly
Jan 1, 2011·Cancers·Arlhee Diaz, Kalet Leon
Feb 24, 2015·World Journal of Experimental Medicine·Cecilia Söderberg-Nauclér, John Inge Johnsen
May 21, 2015·World Journal of Experimental Medicine·Miguel Angel Chiurillo
Aug 6, 2018·Journal of Cellular Physiology·Natália Barreto Dos SantosCatarina Rapôso
Feb 9, 2020·Journal of Clinical Pathology·Hisham F Bahmad, Robert J Poppiti

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis