Cancer stem cells and the impact of Chinese herbs, isolates and other complementary medical botanicals: a review

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Daniel A WeberGeoffrey M Currie

Abstract

To elucidate the connection between the origin of certain cancers and stem cells, cancer stem cells, the stem cell niche and the tumor microenvironment, and to examine the ability of traditional Chinese herbal medicines and isolates in treating these types of cancers, the existing literature was examined and eight studies regarding Chinese herbal medicines and the prevention of cancer recurrence were critically analyzed and evaluated. Tumor stem cells may be the final target of traditional Chinese medicine. Soy flavones, ginsenoside Rg3, parthenolide, berbamine and curcumin are several examples of Chinese herbal medicines, which have been shown to be effective in the treatment of cancer, and seem to act by targeting cancer stem cells and associated pathways resulting in tumorigenesis. The treatment approaches combined with an overall treatment protocol for the tumor microenvironment and chronic systemic inflammation are likely to provide a more successful outcome than a single tactical approach. As shown in numerous studies in the literature, using complementary disciplines with orthodox treatments may enhance treatment outcomes.

Citations

Feb 7, 2015·Journal of Medicinal Food·Jisun OhYong-Seob Jeong
Apr 25, 2017·CA: a Cancer Journal for Clinicians·Heather GreenleeDebu Tripathy
Jul 15, 2017·Molecular Pharmacology·Alison GardnerMichael C Sanguinetti
Nov 1, 2013·Molecular Medicine Reports·Lihui WeiJun Peng
Feb 13, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Margaret ReesCorrado Terranova

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