Cancer stem cells: at the forefront of personalized medicine and immunotherapy

Current Opinion in Pharmacology
Micol E FioriRuggero De Maria

Abstract

Cancer stem cells (CSCs) represent the main target of the current efforts to eradicate cancer, because of their ability to promote metastatic dissemination and survive cytotoxic therapies. Here, we highlight the potential of patient-derived CSCs as an in vitro and in vivo pre-clinical model and of liquid biopsy as a diagnostic, prognostic and predictive tool. We discuss recently developed therapeutic strategies aiming at specifically targeting the cancer stem cell population, particularly focusing on the latest advances in cancer immunotherapy. In fact, it is now widely accepted that the microenvironment plays an active role in supporting tumor progression. Hence, the crosstalk between CSCs and the host immune system is nowadays object of intensive study, with the aim to develop effective therapeutic strategies targeting the ability of CSCs to escape immune-surveillance through immunoediting.

Citations

Sep 6, 2017·Genes·Rachael A WyattBryan D Crawford
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Nov 23, 2017·Cancer Cell International·Du-Chu ChenDemeng Chen
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May 30, 2019·Cancers·Masahiro Shibata, Mohammad Obaidul Hoque
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Apr 5, 2020·International Journal of Molecular Sciences·Lidia VillanovaMicol Eleonora Fiori
Nov 17, 2020·Frontiers in Immunology·Antonella SistiguRuggero De Maria
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Mar 19, 2021·Frontiers in Cell and Developmental Biology·Peijie WuNa Xie
Oct 15, 2021·Journal of Experimental & Clinical Cancer Research : CR·Marco GiordanoUgo Cavallaro

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