Cancer Stem Cells in Pheochromocytoma and Paraganglioma.

Frontiers in Endocrinology
Laura D ScribaCharlotte Steenblock

Abstract

Pheochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumors associated with high cardiovascular morbidity and variable risk of malignancy. The current therapy of choice is surgical resection. Nevertheless, PCCs/PGLs are associated with a lifelong risk of tumor persistence or recurrence. A high rate of germline or somatic mutations in numerous genes has been found in these tumors. For some, the tumorigenic processes are initiated during embryogenesis. Such tumors carry gene mutations leading to pseudohypoxic phenotypes and show more immature characteristics than other chromaffin cell tumors; they are also often multifocal or metastatic and occur at an early age, often during childhood. Cancer stem cells (CSCs) are cells with an inherent ability of self-renewal, de-differentiation, and capacity to initiate and maintain malignant tumor growth. Targeting CSCs to inhibit cancer progression has become an attractive anti-cancer therapeutic strategy. Despite progress for this strategy for solid tumors such as neuroblastoma, brain, breast, and colon cancers, no substantial advance has been made employing similar strategies in PCCs/PGLs. In the current review, we discuss findings related to the identification of normal ...Continue Reading

References

Jan 1, 1993·Annual Review of Neuroscience·D J Anderson
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·A G Knudson
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul J ZhangVirginia A LiVolsi
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tania CrombetAgustín Lage
Aug 17, 2005·PLoS Genetics·Patricia L M DahiaCharles D Stiles
Aug 23, 2005·Lancet·Jacques W M LendersKarel Pacak
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Linheng Li, Ting Xie
Jan 26, 2006·The American Journal of Surgical Pathology·Sean K LauLawrence M Weiss
May 24, 2008·Molecular Cell·William G Kaelin, Peter J Ratcliffe
Jan 31, 2009·Science·Lori L AndersonC Michael Crowder
Jul 18, 2009·Stem Cells·Kuei-Fang ChungMonika Ehrhart-Bornstein
Sep 4, 2009·The New England Journal of Medicine·Daniel D Von HoffJennifer A Low
Jan 12, 2010·Developmental Cell·Sally L Dunwoodie
May 1, 2010·Neoplasma·O KrupkovaR Veselska
Nov 6, 2010·Endocrine-related Cancer·Graeme EisenhoferJacques W M Lenders
Dec 15, 2010·The Journal of Clinical Endocrinology and Metabolism·Graeme EisenhoferKarel Pacak
Jul 26, 2011·Human Molecular Genetics·Nelly BurnichonAnne-Paule Gimenez-Roqueplo
Aug 31, 2012·The New England Journal of Medicine·Zhengping ZhuangKarel Pacak
Nov 20, 2012·Advances in Experimental Medicine and Biology·Denis CorbeilJózsef Jászai
Dec 1, 2012·Stem Cells Translational Medicine·Magda M SantanaMonika Ehrhart-Bornstein
Apr 17, 2013·The American Journal of Surgical Pathology·Riley E AlexanderMuhammad Idrees
Jun 20, 2013·Neural Development·Stella ShtukmasterKlaus Unsicker
Aug 24, 2013·Science·Yoshiko TakahashiHideki Enomoto
Oct 12, 2013·PloS One·Barbara HämmerleJaime Font de Mora
Jan 1, 2011·Cancers·Arlhee Diaz, Kalet Leon
Nov 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Alexandre BuffetAnne-Paule Gimenez-Roqueplo
Jan 21, 2014·Nature Reviews. Cancer·Patricia L M Dahia
Mar 29, 2014·International Journal of Cancer. Journal International Du Cancer·Nan QinGraeme Eisenhofer
Aug 1, 2014·Nature·Nina KaukuaIgor Adameyko
Dec 30, 2014·The Journal of Pathology·Aidan FlynnRichard W Tothill
Jan 13, 2015·Development, Growth & Differentiation·Rachael Lumb, Quenten Schwarz
Mar 25, 2015·Stem Cells·Maria F Rubin de CelisMonika Ehrhart-Bornstein
May 16, 2015·Journal of Pediatric Surgery·Todd JensenChristine Finck
Aug 11, 2015·Analytical Cellular Pathology (Amsterdam)·Alfred Buhagiar, Duncan Ayers
Oct 7, 2015·British Journal of Cancer·Carla MicucciAlfonso Catalano
Jun 15, 2016·Biochemical and Biophysical Research Communications·Brian T CraigDai H Chung

❮ Previous
Next ❯

Citations

May 13, 2020·Stress : the International Journal on the Biology of Stress·Stefan R BornsteinCharlotte Steenblock
Sep 10, 2020·Fetal and Pediatric Pathology·Junzuo LiaoYun Liang
Jan 13, 2021·Endocrine Pathology·Thomas G PapathomasRonald R de Krijger
Apr 3, 2021·Molecular and Cellular Endocrinology·Nicole BechmannCharlotte Steenblock
Aug 21, 2020·Molecular and Cellular Endocrinology·Maria Eleni KastritiIgor Adameyko
Sep 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Deepika WattsBen Wielockx

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Stem Cell Investigation
Amanda K TempletonRajagopal Ramesh
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Mengqi YangPeng Huang
© 2021 Meta ULC. All rights reserved