Cancer stratification by molecular imaging

International Journal of Molecular Sciences
Justus WeberWalter Mier

Abstract

The lack of specificity of traditional cytotoxic drugs has triggered the development of anticancer agents that selectively address specific molecular targets. An intrinsic property of these specialized drugs is their limited applicability for specific patient subgroups. Consequently, the generation of information about tumor characteristics is the key to exploit the potential of these drugs. Currently, cancer stratification relies on three approaches: Gene expression analysis and cancer proteomics, immunohistochemistry and molecular imaging. In order to enable the precise localization of functionally expressed targets, molecular imaging combines highly selective biomarkers and intense signal sources. Thus, cancer stratification and localization are performed simultaneously. Many cancer types are characterized by altered receptor expression, such as somatostatin receptors, folate receptors or Her2 (human epidermal growth factor receptor 2). Similar correlations are also known for a multitude of transporters, such as glucose transporters, amino acid transporters or hNIS (human sodium iodide symporter), as well as cell specific proteins, such as the prostate specific membrane antigen, integrins, and CD20. This review provides a co...Continue Reading

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Citations

Oct 11, 2016·Biomarkers in Cancer·Martin C BoonstraCornelis F M Sier
Jun 24, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vincent BouvetFrank Wuest
Jan 26, 2021·Bioorganic & Medicinal Chemistry·Ana Cláudia Camargo MirandaElaine Bortoleti de Araújo
Aug 21, 2021·Bioconjugate Chemistry·Maruthi Kumar NarayanamJennifer M Murphy
Jul 30, 2020·Advanced Drug Delivery Reviews·Carlos Pérez-MedinaRoy van der Meel

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Methods Mentioned

BETA
imaging techniques
biopsy
X-ray
imaging technique

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