Cancer surgery: how may anesthesia influence outcome?

Journal of Clinical Anesthesia
Fernando CassinelloGary R Strichartz

Abstract

To review the published literature regarding the effects of anesthesia on cancer surgery to prevent tumor cell proliferation/migration or induce apoptosis. Surgery is the main treatment for potentially curable solid tumors, but most cancer-related deaths in patients who have received previous surgical treatment are caused by metastatic disease. There is increasing evidence that anesthetic technique has the potential to affect long-term outcome after cancer surgery. This work reviews the English published literature that was obtained by performing a search of the PubMed database up to January 2014. We selected articles that provided evidence or reviewed the possible actions of anesthetics on cancer cells or the influence of anesthesia in recurrence/outcome. Inhaled anesthetics induce immunosuppression and activate inflammatory cascade activation, whereas propofol has a protective action. Opioids might promote cancer recurrence and metastasis. In vitro and in vivo studies have demonstrated that local anesthetics inhibit proliferation and migration of cancer cells and induce apoptosis. Anesthesiologists should follow current best clinical practice and include all strategies that effectively decrease pain and attenuate stress. Regi...Continue Reading

References

Apr 1, 1990·Anesthesiology·J F Butterworth, G R Strichartz
Sep 1, 1981·The Journal of Clinical Investigation·J ShapiroS Segal
Mar 15, 1997·Experimental Cell Research·M KimR D Wurster
Sep 7, 2000·Biochemical Pharmacology·K AritaK Utsumi
Jul 24, 2001·Anesthesiology·S Bar-YosefS Ben-Eliyahu
Feb 28, 2002·The Journal of Biological Chemistry·Yoko AraiMinoru Kasuya
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 5, 2003·Biochemical Pharmacology·Gang WeiChun Su Yuan
Aug 6, 2005·AACN Clinical Issues·Gayle Giboney Page
Apr 14, 2006·Neuroimmunomodulation·Irena Martin-KleinerJelka Gabrilovac
Jul 14, 2006·Breast Cancer Research and Treatment·William J BrackenburyMustafa B A Djamgoz
Aug 22, 2006·Current Drug Targets·Carla Palma
Sep 29, 2006·Anesthesiology·Aristomenis K ExadaktylosDaniel I Sessler
Oct 24, 2006·The British Journal of Surgery·T G Allen-MershS K Jonas
Feb 20, 2007·The International Journal of Biochemistry & Cell Biology·Sébastien RogerJean-Yves Le Guennec
Dec 8, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·J A González-CorreaJ P De La Cruz
Jun 14, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DemicheliI D Gukas
Aug 8, 2008·Journal of Anesthesia·Shin Kurosawa, Masato Kato
Oct 11, 2008·The British Journal of Surgery·E MarretF Bonnet
Sep 1, 2007·Hepatology International·Motohisa TadaOsamu Yokosuka
Aug 25, 2009·British Journal of Anaesthesia·R WerdehausenM F Stevens
Oct 22, 2009·Anesthesia and Analgesia·Israel Z YardeniHanna Bessler
Nov 17, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ban C H TsuiBrendan T Finucane
Dec 2, 2009·The International Journal of Biochemistry & Cell Biology·Athina-Myrto ChioniMustafa B A Djamgoz
May 29, 2010·Anesthesiology·Antje GottschalkEdward C Nemergut
Jul 16, 2010·British Journal of Anaesthesia·G L Snyder, S Greenberg
Aug 12, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ji-Eun KimHyun Kyung Kim
Aug 31, 2010·Future Oncology·Patrick A Singleton, Jonathan Moss

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Citations

Sep 22, 2015·Current Anesthesiology Reports·Li JiangAnil K Sood
Jun 7, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T Piegeler, B Beck-Schimmer
Oct 21, 2016·International Journal of Surgery·I SellbrantJ G Jakobsson
Oct 30, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F JankuJ Moss
Oct 28, 2016·F1000Research·Jan Jakobsson, Mark Z Johnson
Aug 19, 2017·Scientific Reports·Shun-Ming ChanZhi-Fu Wu
Aug 3, 2019·The Journal of Pharmacy and Pharmacology·Jianghui LuoXudong Zhang
Nov 28, 2019·Experimental and Therapeutic Medicine·Hua Yan ChenJi Ying Zhong
Mar 30, 2020·Scientific Reports·Stefan J GrauThorsten Annecke
Aug 18, 2018·Drugs·Marc BeaussierLuc Mercadal
Dec 19, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Greggory J MartinezJohn P McCallin
Apr 24, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yan-Ling Ren, Wei Zhang
Feb 14, 2021·Acta Anaesthesiologica Scandinavica·Mats Enlund
Feb 26, 2021·The Cochrane Database of Systematic Reviews·Anjolie ChhabraMani Kalaivani

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