Jan 31, 2019

Cancer Target Gene Screening: a web application for breast cancer target gene screening using multi-omics data analysis

Briefings in Bioinformatics
Hyung-Yong KimGu Kong

Abstract

Breast cancer comprises several molecular subtypes with distinct clinical features and treatment responses, and a substantial portion of each subtype remains incurable. A comprehensive analysis of multi-omics data and clinical profiles is required in order to better understand the biological complexity of this cancer type and to identify new prognostic and therapeutic markers. Thus, there arises a need for useful analytical tools to assist in the investigation and clinical management of the disease. We developed Cancer Target Gene Screening (CTGS), a web application that provides rapid and user-friendly analysis of multi-omics data sets from a large number of primary breast tumors. It allows the investigation of genomic and epigenomic aberrations, evaluation of transcriptomic profiles and performance of survival analyses and of bivariate correlations between layers of omics data. Notably, the genome-wide screening function of CTGS prioritizes candidate genes of clinical and biological significance among genes with copy number alteration, DNA methylation and dysregulated expression by the integrative analysis of different types of omics data in customized subgroups of breast cancer patients. These features may help in the identi...Continue Reading

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References

Mentioned in this Paper

Biological Markers
Clinical Management
Genome
Genes
Candidate Disease Gene
DNA Methylation
Survival Analysis
Evaluation
Chromosome Aberrations
Gene Expression Profiling

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