Cancer Therapeutic Proficiency of Dual-Targeted Mesoporous Silica Nanocomposite Endorses Combination Drug Delivery

ACS Omega
Chandran MuruganSoundarapandian Kannan

Abstract

The cargo-loaded mesoporous silica nanoparticles (MSNs) with convenient surface modification can facilitate the development of the innovative nanodrug system. Herein, the present investigation described the electrostatically self-assembled MSNs as a nanosized drug carrier to realize potent synergistic chemotherapy based on the specificity in targeting cytoplasm and nucleus of tumor cells. In this context, the primarily constructed MSNs were subjected with anticancer drug topotecan (TPT) into its large pores. Then, the selective TAT peptide (a nuclear localization signal peptide) was anchored onto TPT-loaded MSNs (TPT-MSN). Subsequently, the positive surface of TPT-MSN-TAT was capped with negatively charged components, poly(acrylic acid) (PAA)-cRGD peptide and citraconic anhydride (CAH)-metformin (MT), and acted as a smart gatekeeper. Comparatively, PAA-cRGD attached onto MSNs serving as the targeted molecules could upsurge by invasion into cancer cells. Interestingly, the acidic pH of the lysosomal compartment in tumor cells triggers the conjugated CAH from the polymer decorated mesoporous silica (PMS) nanocomposite and could efficiently release MT into the cytoplasm. Consequently, the remaining TPT-MSN-TAT efficiently targets ...Continue Reading

References

Jan 5, 2000·Cell·S Nakielny, G Dreyfuss
Jan 20, 2005·The Journal of Cell Biology·Ulrich KubitscheckReiner Peters
Oct 26, 2005·Drug Discovery Today·Francesco M Veronese, Gianfranco Pasut
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Kyle R LegateReinhard Fässler
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Mar 3, 2007·Progress in Cardiovascular Diseases·Genzou Takemura, Hisayoshi Fujiwara
Nov 30, 2007·Nature·Frank AlberMichael P Rout
Aug 9, 2008·International Journal of Nanomedicine·Wim H De Jong, Paul J A Borm
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stephanie E A GrattonJoseph M DeSimone
Mar 13, 2009·Journal of the American Chemical Society·Pieter E S SmithAyyalusamy Ramamoorthy
Mar 31, 2009·Toxicology and Applied Pharmacology·Yan-Juan GuWing-Tak Wong
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Sep 24, 2009·Journal of the American Chemical Society·Jutaek NamSungjee Kim
Oct 31, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·P DecuzziM Ferrari
Dec 18, 2009·Cardiology·Kanu ChatterjeeJoel S Karliner
Jan 21, 2010·Journal of the American Chemical Society·Bin KangMostafa A El-Sayed
Sep 15, 2010·Molecular Pharmaceutics·Weiwei GaoOmid C Farokhzad
Sep 28, 2010·Advanced Drug Delivery Reviews·Kazuo Maruyama
Apr 5, 2011·Nature Nanotechnology·Kohei YamashitaYasuo Tsutsumi
May 21, 2011·Journal of the American Chemical Society·Min XueJeffrey I Zink
Aug 19, 2011·Accounts of Chemical Research·Ji Eun LeeTaeghwan Hyeon
Aug 26, 2011·Pharmaceutical Development and Technology·Meltem CetinImran Vural
Dec 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kiran Ramanlal ChaudhariRayasa S Ramachandra Murthy
Jan 17, 2012·Toxicology and Applied Pharmacology·Javed AhmadAbdulaziz A Al-Khedhairy
Mar 17, 2012·Journal of the American Chemical Society·Limin PanJianlin Shi
Jan 30, 2014·International Journal of Biological Macromolecules·Raju VivekSoundarapandian Kannan
Apr 16, 2014·Journal of Nanoscience and Nanotechnology·Minghui LiQun Wang
Jul 15, 2015·ACS Applied Materials & Interfaces·Hong ChengXian-Zheng Zhang
Nov 9, 2016·Journal of Colloid and Interface Science·Karuppaiya VimalaSoundarapandian Kannan

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Citations

Dec 4, 2020·International Journal of Nanomedicine·Xiaowei WangRongguang Shao
Dec 24, 2020·International Journal of Molecular Sciences·Miguel Gisbert-GarzaránMaría Vallet-Regí
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xia NiuGuiling Li
Sep 1, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manyue ZhangPeng Zhang

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Methods Mentioned

BETA
PMS
dynamic light scattering
Scanning Microscopy
fluorescence microscopy
Fluorescence
Flow cytometry
Assay
ELISA

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