PMID: 9430587Feb 7, 1998Paper

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

Science
W ArapE Ruoslahti

Abstract

In vivo selection of phage display libraries was used to isolate peptides that home specifically to tumor blood vessels. When coupled to the anticancer drug doxorubicin, two of these peptides-one containing an alphav integrin-binding Arg-Gly-Asp motif and the other an Asn-Gly-Arg motif-enhanced the efficacy of the drug against human breast cancer xenografts in nude mice and also reduced its toxicity. These results indicate that it may be possible to develop targeted chemotherapy strategies that are based on selective expression of receptors in tumor vasculature.

References

Jan 1, 1991·Annals of the New York Academy of Sciences·T R ShockleyM L Yarmush
Nov 23, 1973·Nature·M R GeierC R Merril
Jan 1, 1980·Methods in Enzymology·S Bauminger, M Wilchek
Dec 1, 1995·Science·M FriedlanderD A Cheresh
Apr 22, 1994·Science·P C BrooksD A Cheresh
Oct 1, 1994·Pharmacology & Therapeutics·F J Burrows, P E Thorpe
Dec 1, 1995·Current Opinion in Biotechnology·G Martiny-Baron, D Marmé
Mar 28, 1996·Nature·R Pasqualini, E Ruoslahti
Jan 1, 1995·Annual Review of Cell and Developmental Biology·W Risau, I Flamme
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ Horvath
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Apr 17, 1997·Nature·W Risau
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·R MaxR M De Waal
Jun 1, 1997·Nature Biotechnology·J Folkman
Jun 1, 1997·Nature Biotechnology·R PasqualiniE Ruoslahti
Aug 1, 1997·Academic Medicine : Journal of the Association of American Medical Colleges·B L Cardin

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Citations

Sep 25, 1999·International Journal of Cancer. Journal International Du Cancer·D CéfaïC D Gimmi
Apr 16, 1999·Muscle & Nerve·T I Samoylova, B F Smith
Mar 21, 2000·Medicinal Research Reviews·A Leone-BayJ J Weidner
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S H Kaufmann, G J Gores
Sep 5, 2002·Arthritis and Rheumatism·Lewis LeeCostantino Pitzalis
Oct 18, 2002·Biopolymers·Olulanu H AinaKit S Lam
May 27, 2003·Biopolymers·Feng-Di T Lung, Jya-Yin Tsai
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Alfonso CalvoJeffrey E Green
Nov 15, 2002·International Journal of Cancer. Journal International Du Cancer·Astrid J SchraaGrietje Molema
Oct 17, 2002·Journal of Molecular Recognition : JMR·Alexandre M SamoylovVitaly J Vodyanoy
Apr 13, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Aleksander SochanikStanisław Szala
Feb 27, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ning DingShouzhang She
Mar 27, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Benedetta BussolatiGiovanni Camussi
Mar 17, 2010·Archives of Microbiology·Paulina BudynekAndrzej Górski
Jul 27, 2010·Analytical and Bioanalytical Chemistry·Anthony J TavaresUlrich J Krull
Jun 28, 2011·Cancer Chemotherapy and Pharmacology·Xing-Chen PengJi-Yan Liu
Aug 30, 2008·Cell and Tissue Research·Dietmar W Siemann, Michael R Horsman
Aug 30, 2008·Cell and Tissue Research·William C Aird
Feb 4, 2009·Clinical and Experimental Medicine·Song NalingWen Lei
Oct 18, 2008·Angiogenesis·Arvind P PathakMichael S Pepper
Dec 29, 2011·Angiogenesis·Lynn M KnowlesJan Pilch
Aug 12, 2009·Biomedical Microdevices·Glauco R SouzaWadih Arap
Dec 1, 2007·Cancer Metastasis Reviews·Philip Y Wai, Paul C Kuo
Dec 19, 2009·Journal of Computer-aided Molecular Design·Eunkyoung JungDong Hyun Jung
Oct 30, 2012·Journal of Computer-aided Molecular Design·Eunkyoung JungDong Hyun Jung
Mar 23, 2007·Pharmaceutical Research·Xiaomin FanCatherine M Woods
Jun 4, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Toshiro KitagawaMichael V McConnell
Jun 20, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaohua ZhuDan Zhu
Apr 2, 2003·Current Atherosclerosis Reports·Lorraine M WorkAndrew H Baker
Jun 8, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Angelo CortiVanesa Gregorc
Feb 27, 2004·Biochimica Et Biophysica Acta·Patrizia AlessiDario Neri
Feb 27, 2004·Biochimica Et Biophysica Acta·Aernout LuttunPeter Carmeliet

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