Cancer vaccine--Antigenics

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy

Abstract

Antigenics is developing a therapeutic cancer vaccine based on heat-shock proteins (HSPs). The vaccine [HSPPC-96, Oncophage] is in a pivotal phase III clinical trial for renal cancer at 80 clinical sites worldwide. The trial is enrolling at least 500 patients who are randomised to receive surgical removal of the primary tumour followed by out-patient treatment with Oncophage((R)) or surgery only. This study was initiated on the basis of results from a pilot phase I/II study and preliminary results from a phase II study in patients with renal cell cancer. In October 2001, Oncophage was designated as a fast-track product by the Food and Drug Administration in the US for the treatment of renal cell carcinoma. Oncophage is in phase I/II trials in Italy for colorectal cancer (30 patients) and melanoma. The trials in Italy are being conducted at the Istituto dei Tumouri, Milan (in association with Sigma-Tau). Preliminary data from the phase II trial for melanoma was presented at the AACR-NCI-EORTC International Conference in Florida, USA, in October 2001. Oncophage is also in a phase I/II (42 patients) and a phase II trial (84 patients) in the US for renal cell cancer, a phase II trial in the US for non-Hodgkin's lymphoma (35 patient...Continue Reading

Citations

Dec 31, 2003·Southern Medical Journal·Yoav AvidorHaim Matzkin
Dec 1, 2009·Neurosurgery Clinics of North America·Isaac YangAndrew T Parsa
Aug 9, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M M AloysiusO Eremin
Nov 21, 2007·Surgical Oncology Clinics of North America·Robert J Amato
Apr 1, 2003·Expert Opinion on Investigational Drugs·Mayer Fishman, Scott Antonia
Dec 17, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jamie Poust
May 17, 2005·BJU International·Andrea Mancuso, Cora N Sternberg

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