CancerLivER: a database of liver cancer gene expression resources and biomarkers.

Database : the Journal of Biological Databases and Curation
Harpreet KaurGajendra Ps Raghava

Abstract

Liver cancer is the fourth major lethal malignancy worldwide. To understand the development and progression of liver cancer, biomedical research generated a tremendous amount of transcriptomics and disease-specific biomarker data. However, dispersed information poses pragmatic hurdles to delineate the significant markers for the disease. Hence, a dedicated resource for liver cancer is required that integrates scattered multiple formatted datasets and information regarding disease-specific biomarkers. Liver Cancer Expression Resource (CancerLivER) is a database that maintains gene expression datasets of liver cancer along with the putative biomarkers defined for the same in the literature. It manages 115 datasets that include gene-expression profiles of 9611 samples. Each of incorporated datasets was manually curated to remove any artefact; subsequently, a standard and uniform pipeline according to the specific technique is employed for their processing. Additionally, it contains comprehensive information on 594 liver cancer biomarkers which include mainly 315 gene biomarkers or signatures and 178 protein- and 46 miRNA-based biomarkers. To explore the full potential of data on liver cancer, a web-based interactive platform was d...Continue Reading

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Citations

Apr 1, 2021·Briefings in Functional Genomics·Harpreet KaurGajendra P S Raghava
Aug 28, 2021·Biomedicines·Sedigheh FalahiYvonne Joseph

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Methods Mentioned

BETA
array technique
RNA-Seq

Software Mentioned

lumi
Hs
CancerCSP
. db
Affymetrix
BioXpress
R
GSVA
Dataset Search
OncoMX

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