Cancers of the colon and rectum: identical or fraternal twins?

Cancer Discovery
Theodore S HongKevin M Haigis

Abstract

Colorectal cancer represents a major cause of cancer morbidity and mortality, with approximately 1.2 million cases and 600,000 deaths worldwide each year. Because of the anatomic continuity of the colon into the rectum, cancers affecting these organs have historically been considered equivalent. In this Prospective, we discuss the clinical and experimental data suggesting that colon cancer and rectal cancer are highly related, but distinct, diseases. Reconsidering the relationship between these cancers has implications for the development of new therapeutic paradigms.

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Citations

Dec 19, 2013·PloS One·Laura B KleimanKevin M Haigis
Sep 17, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ioannis D KostakisMichael Koutsilieris
May 27, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ioannis D KostakisMichael Koutsilieris
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Mar 19, 2019·Future Oncology·Savio George Barreto
Dec 17, 2019·Diseases of the Colon and Rectum·Melannie S AlexanderKangmin Zhu
Mar 8, 2020·International Journal of Molecular Sciences·Vincent HoCheok Soon Lee
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May 6, 2021·Biomaterials Science·Maria José SilveiraBruno Sarmento
Jun 3, 2021·Cadernos de saúde pública·Mariana Araujo Neves Lima, Daniel Antunes Maciel Villela

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