Candesartan cilexetil improves angiotensin II type 2 receptor-mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin-resistant rats.

Diabetes
Narumi Hashikawa-HobaraHiromu Kawasaki

Abstract

We have shown previously that stimulation of the angiotensin II type 2 receptor (AT(2)R) results in nerve facilitation. In this study, we determined the capacity of candesartan to correct expression patterns characteristic of neuropathy and AT(2)R-mediated neurite outgrowth in the fructose-induced insulin-resistant rat, which is one of the human hyperinsulinemia models. Wistar rats received a 15% (w/v) fructose solution in their drinking water for 4 weeks (fructose-drinking rats [FDRs]), with or without candesartan (5 mg/kg/day). We evaluated physiological and behavioral parameters and performed immunohistochemical studies. We found that the FDR developed insulin resistance and downregulated both AT(2)R neuronal function and phosphorylated Akt expression in dorsal root ganglia (DRG) neurons. Candesartan improved neurite outgrowth in the FDR, which was associated with the restoration of AT(2)R and phosphorylated Akt expression. Furthermore, downregulation of phosphoinositide 3-kinase (PI3K) inhibited AT(2)R-mediated neurite outgrowth in control DRG cells. PI3K activation increased AT(2)R-mediated neurite outgrowth and phosphorylated Akt expression in FDR DRG cells. These results suggest that the decrease of AT(2)R-mediated neuri...Continue Reading

References

Jun 1, 1989·The American Journal of Clinical Nutrition·A W ThorburnE W Kraegen
Nov 27, 1999·Science·S Zimmermann, K Moelling
Apr 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jianmin RanMitsuru Adachi
Jul 3, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Bonny L BukaveckasMark W Linder
Feb 25, 2005·American Journal of Physiology. Endocrinology and Metabolism·Christine L OltmanMark A Yorek
Apr 2, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Yoshihiro TaniyamaKathy K Griendling
Jun 9, 2005·Hypertension·Ronald ClasenUlrich Kintscher
Aug 29, 2006·Diabetes Research and Clinical Practice·Masahiko IgarashiMakoto Tominaga
Sep 20, 2006·The Journal of Biological Chemistry·Yongzhong WeiCraig S Stump
Feb 5, 2008·British Journal of Pharmacology·S TakatoriH Kawasaki
Jan 20, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ming-Sheng ZhouLeopoldo Raij
Jun 9, 2009·Cellular and Molecular Life Sciences : CMLS·Danielle E Read, Adrienne M Gorman
Oct 10, 2009·British Journal of Pharmacology·J C RussellS D Proctor
Jul 29, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshito ZamamiHiromu Kawasaki

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Citations

Dec 6, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ahmed AlhusbanSusan C Fagan
Nov 2, 2013·Life Sciences·Seung Ah ChaSuhn Hee Kim
Jun 25, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gali UmschweifEsther Shohami
Jan 16, 2013·International Journal of Hypertension·Marie-Odile Guimond, Nicole Gallo-Payet
Jan 25, 2014·The Journal of Nutritional Biochemistry·Chen-Yu FanLing-Dong Kong
Jun 8, 2012·Journal of Pharmacological Sciences·Narumi Hashikawa-HobaraHiromu Kawasaki
Aug 16, 2016·Biochemical and Biophysical Research Communications·Narumi Hashikawa-Hobara, Naoya Hashikawa
Nov 3, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shingo Takatori

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