PMID: 10697305Mar 4, 2000Paper

Candesartan cilexetil in hypertension: effects of six weeks' treatment on haemodynamics, baroreceptor sensitivity and the renin-angiotensin-aldosterone system

Blood Pressure
K FridmanO K Andersson

Abstract

The effects of the angiotensin II receptor blocker candesartan cilexetil on systemic and forearm haemodynamics and baroreceptor sensitivity were evaluated in this randomized, placebo-controlled, double-blind, crossover study. After a 4-week placebo run-in period, 22 patients with essential hypertension (diastolic blood pressure 100-114 mmHg) were randomized to receive either candesartan cilexetil 16 mg or placebo once daily for 6 weeks. At the end of each period, 24 h after the last dose, invasive haemodynamic assessments were performed. Simultaneously, the plasma renin activity and plasma concentrations of angiotensin II, aldosterone and catecholamines were measured. Compared to placebo, candesartan cilexetil significantly reduced mean arterial pressure by 8 mmHg (95% CI: 2.6; 12.3), while cardiac output, stroke volume and heart rate were unchanged. Forearm vascular resistance was reduced by 1 mmHg x ml(-1) x L x min (CI: 0.3; 2.3). The baroreceptor sensitivity was not influenced, but a change in the set-point was noted. Plasma renin activity and angiotensin II concentrations were increased, while the aldosterone concentration was significantly reduced. Plasma catecholamine concentrations were unaffected. In conclusion, 6 week...Continue Reading

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Citations

Jan 5, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S Ichikawa, Y Takayama
Jan 30, 2008·Medical & Biological Engineering & Computing·Michael J Mulvany
May 16, 2002·Drugs·Stephanie E Easthope, Blair Jarvis
Dec 14, 2004·Cardiovascular Drug Reviews·Christoph H GleiterKlaus Mörike
Aug 9, 2007·Journal of the Cardiometabolic Syndrome·Kazuo EguchiKazuomi Kario
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Balraj S HeranJames M Wright

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