Candesartan cilexetil plus hydrochlorothiazide combination: a review of its use in hypertension

Drugs
Ezequiel Balmori Melian, Blair Jarvis

Abstract

The combination of candesartan cilexetil [an angiotensin II type 1 (AT(1)) receptor antagonist] plus hydrochlorothiazide (a thiazide diuretic), has been used in the treatment of patients with hypertension. The blood pressure (BP) lowering effect of various doses of this combination, administered orally once a day for 4 to 52 weeks, has been demonstrated in clinical trials. These studies showed that combinations of candesartan cilexetil 4 to 16 mg with hydrochlorothiazide 12.5 or 25 mg induced significant reductions reductions in systolic (S) BP and diastolic (D) BP from baseline in patients with mild to severe hypertension. Data from clinical trials indicated that reductions in BP induced by candesartan cilexetil 4 to 32 mg/hydrochlorothiazide 12.5 mg combinations were significantly greater than those observed after monotherapy with either drug. Treatment for 8 weeks with candesartan cilexetil 16 mg/hydrochlorothiazide 12.5 mg or candesartan cilexetil 16 mg induced SBP/DBP reductions of 12.0/7.5 mm Hg and 7.5/5.5mm Hg, respectively (p < 0.05 both comparisons). Moreover, data from a randomised, double-blind, placebo-controlled, dose-finding study in 1038 patients with mild to moderate hypertension showed that the greatest reduct...Continue Reading

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Citations

Mar 5, 2004·American Journal of Therapeutics·Ramesh M GowdaTerrence J Sacchi
May 16, 2002·Drugs·Stephanie E Easthope, Blair Jarvis
Sep 24, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Sheridan M Hoy, Gillian M Keating
Dec 10, 2003·Expert Opinion on Emerging Drugs·J A Whitworth
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May 20, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Peter A Meredith

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