Candida albicans dampens host defense by downregulating IL-17 production

The Journal of Immunology : Official Journal of the American Association of Immunologists
Shih-Chin ChengMihai G Netea

Abstract

IL-17 is one of the key cytokines that stimulate host defense during a Candida infection. Several studies have demonstrated the capacity of Candida albicans to induce a Th17 response. Surprisingly, experiments employing live C. ablicans demonstrated a specific downregulation of host IL-17 secretion in human blood mononuclear cells (PBMCs). By avoiding the direct contact of live C. albicans and PBMCs, we demonstrate that this inhibition effect is mediated by a soluble factor released by live C. albicans. However, this effect is due neither to the releasing of C. albicans pathogen-associated molecular patterns nor to the alteration of different Th cell subtypes. Rather, we found that live C. albicans shifts tryptophan metabolism by inhibiting IDO expression away from kynurenines and toward 5-hydroxytryptophan metabolites. In addition, we show that these latter 5-hydroxytryptophan metabolites inhibit IL-17 production. In conclusion, live C. albicans inhibits host Th17 responses by modulatory effects on tryptophan metabolism.

References

Jan 1, 1987·Critical Reviews in Microbiology·N A Gow, G W Gooday
Jun 1, 1969·Journal of Bacteriology·R I Lehrer, M J Cline
Aug 6, 2002·Journal of Neuroimmunology·Kenichi SakuraiGene M Shearer
Sep 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Julian R NaglikBernhard Hube
Jan 15, 2004·Trends in Molecular Medicine·David H Munn, Andrew L Mellor
Jun 23, 2004·Advances in Experimental Medicine and Biology·Ursula GrohmannPaolo Puccetti
Jul 10, 2004·The Journal of Infectious Diseases·Weitao HuangPaul Schwarzenberger
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia BozzaLuigina Romani
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Mihai G NeteaBart-Jan Kullberg
Oct 22, 2005·Infection and Immunity·Chantal A A van der GraafBart Jan Kullberg
Oct 26, 2005·Journal of Dental Research·A Dongari-Bagtzoglou, P L Fidel
Apr 24, 2007·Nature Immunology·Salomé LeibundGut-LandmannCaetano Reis e Sousa
Jul 4, 2007·Infection and Immunity·Calin PopaMihai G Netea
Nov 17, 2007·The Journal of Infectious Diseases·Neil A R GowBart Jan Kullberg
Apr 29, 2008·Immunology Letters·Maohua ZhouChangyou Wu
Jul 11, 2008·The Journal of Investigative Dermatology·Kilian EyerichClaudia Traidl-Hoffmann
Jan 8, 2009·Immunology·Meredith M Curtis, Sing Sing Way
Jan 24, 2009·Immunological Reviews·Patricia J Dubin, Jay K Kolls
Jan 24, 2009·Trends in Molecular Medicine·Maria L BelladonnaPaolo Puccetti
Feb 11, 2009·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Apr 22, 2009·Cell Host & Microbe·Frank L van de VeerdonkMihai G Netea
Aug 26, 2009·The Journal of Experimental Medicine·Matthew J RobinsonCaetano Reis e Sousa

❮ Previous
Next ❯

Citations

Jul 1, 2011·Immunologic Research·Sarah L GaffenAlanna C Peterson
Dec 20, 2012·Mucosal Immunology·N Hernández-SantosS L Gaffen
Dec 14, 2011·Nature Reviews. Microbiology·Neil A R GowMihai G Netea
Jan 19, 2012·Infection and Immunity·Shih-Chin ChengMihai G Netea
Jul 22, 2011·Clinical & Developmental Immunology·David L Moyes, Julian R Naglik
Dec 24, 2011·PLoS Pathogens·Martin B Dickman, Paul de Figueiredo
Jan 10, 2012·Annual Review of Immunology·Marcel WüthrichBruce Klein
Aug 12, 2014·International Journal of Oral Science·Rui-Qing WuWanJun Chen
Aug 26, 2014·Nucleic Acids Research·Gautam GoelRamnik J Xavier
Feb 26, 2016·Frontiers in Microbiology·S P SmeekensM G Netea
Aug 15, 2015·Pathogens·Florian Sparber, Salomé LeibundGut-Landmann
Dec 23, 2015·Future Medicinal Chemistry·Francesco Antonio GrecoAntonio Macchiarulo
Jan 22, 2015·Virulence·Jonathan P Richardson, David L Moyes
Nov 2, 2014·Frontiers in Immunology·Monica BorghiLuigina Romani
Feb 23, 2017·Microbiome·Francesco StratiCarlotta De Filippo
Dec 2, 2017·Journal of Cutaneous Medicine and Surgery·Aditya K GuptaNeil H Shear
Sep 16, 2015·Infection and Immunity·Louise A Rollins-SmithKevin P C Minbiole
Nov 16, 2013·Nature Reviews. Microbiology·Antonio Cassone
Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Jan 27, 2011·European Journal of Immunology·Teresa ZelanteLuigina Romani
Aug 15, 2012·Immunological Reviews·Tracy L McGahaAndrew L Mellor
Dec 17, 2015·Arthritis Research & Therapy·Tao-Hsiang YangChe-Chun Su
Feb 23, 2020·Frontiers in Immunology·Claudio CostantiniTeresa Zelante
May 25, 2020·Journal of Autism and Developmental Disorders·Rong ZouHuajun Zheng
Oct 15, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L FellerJ Lemmer
Sep 19, 2015·Seminars in Immunopathology·Teresa ZelanteLuigina Romani
Mar 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rong-Yi ChenZongbing You
Feb 19, 2016·The Journal of Biological Chemistry·Lisa RizzettoDuccio Cavalieri
Sep 27, 2019·Frontiers in Immunology·Namarta KaliaManpreet Kaur
Jan 29, 2019·Frontiers in Cellular and Infection Microbiology·Nathália Luísa Sousa de Oliveira MalaccoFrederico Marianetti Soriani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.