Candida albicans group A-specific soluble antigens demonstrated by quantitative immunoelectrophoresis.

Infection and Immunity
R Guinet, S Gabriel

Abstract

Soluble cytoplasmic extracts of Candida albicans groups A and B were prepared and compared by quantitative immunoelectrophoresis experiments performed with a commercial anti-C. albicans group A immune serum. Although crossed immunoelectrophoresis, tandem crossed immunoelectrophoresis, and line immunoelectrophoresis revealed many cross-reactions between the two groups, some components seemed to be specific to group A. However, the complexity of the extracts studied did not allow us to demonstrate specific constituents with these methods. Crossed-line immunoelectrophoresis with and without absorption of antibodies in situ was then used, and four specific antigens unique to group A cytoplasmic extract were demonstrated, one of which appeared to be quantitatively important. The value of various quantitative immunoelectrophoretic methods applied to complex antigenic preparations is discussed.

References

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Citations

Mar 1, 1982·Infection and Immunity·R A Greenfield, J M Jones
Apr 1, 1997·Journal of Clinical Microbiology·A M FreydiereY Gille
Mar 1, 1986·Journal of Clinical Microbiology·J WheatR P Tewari
Aug 1, 1986·European Journal of Clinical Microbiology·D Poulain, J M Pinon
Jan 1, 1991·Critical Reviews in Microbiology·P R Hunter
Jan 1, 1985·Critical Reviews in Microbiology·D PoulainA Vernes

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