Candida albicans in celiac disease: A wolf in sheep's clothing

Autoimmunity Reviews
Lerner Aaron, Matthias Torsten

Abstract

Candida albicans is a commensal fungus with a potential pathogenicity and celiac disease is an autoimmune condition. Both share multiple pathophysiological junctions, including serological markers against cell-wall proteins of Candida, anti-gliadin antibodies are positive in both entities, gluten and a candidal virulence factor share sequence similarity and the autoantigen of celiac disease, the tissue transglutaminase, is pivotal in Candida albicans commensalism and hostile behavior and its covalently cross linked products are stable and resistant to breakdown in the two entities. Those autoimmune/infectious cross roads are the basis for the hypothesis that Candida albicans is an additional environmental factor for celiac disease autoimmunogenesis.

Citations

Mar 17, 2021·Digestive Diseases and Sciences·Mohammad El MouzanMona Alasmi
Jul 1, 2021·Journal of Translational Autoimmunity·Aaron LernerYehuda Shoenfeld
Aug 3, 2021·Nutrition Reviews·Aaron LernerYehuda Shoenfeld

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