Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched Gastrodia elata extracts

Future Microbiology
Xueying CaiDi Wang

Abstract

Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-forming unit (CFU) of vaginal lavage was measured by plating. The extent of the inflammatory response was assessed by hematoxylin-eosin (H&E) staining and enzyme-linked immunosorbent assay (ELISA). Results: GE had an inhibitory effect on the proliferation of C. albicans and inflammatory reaction. Meanwhile, it had a potentially beneficial effect on the growth of Lactobacillus. Conclusion: These results showed the potential application of GE as an antifungal agent in VVC treatment.

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Citations

Jun 17, 2020·International Journal of Biological Macromolecules·Ganeshkumar Arumugam, Rajaram Rajendran

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics

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