Candida albicans versus non-albicans bloodstream infection in patients in a tertiary hospital: an analysis of microbiological data

Scandinavian Journal of Infectious Diseases
George SamonisMatthew E Falagas

Abstract

Considerable changes in the relative frequency of systemic infections due to various Candida species as well as their in vitro susceptibility patterns have been noted in several parts of the world. We performed an analysis of microbiological data of patients with candidaemia at the University general (tertiary) hospital of Heraklion, Greece. During the study period (March 2001 to July 2006) 140 patients had candidaemia. Among them, 64/140 (46%) had candidaemia due to C. albicans and 76/140 (54%) due to non-albicans species (19/76, 25%, C. glabrata; 30/76, 40%, C. tropicalis; 20/76, 26%, C. parapsilosis; 2/76, 3%, C. lusitaniae; 3/76, 4%, C. krusei; and 2/76, 3%, C. guilliermondii). 75 isolates were tested for in vitro susceptibility to antifungal agents with E-test. No isolate was found to be resistant to amphotericin. From 34 C. albicans isolates, 5 (15%) were not susceptible to itraconazole, and 1 (3%) to fluconazole. The C. guilliermondii and the C. lusitaniae isolates were not susceptible to itraconazole. All 11 C. glabrata isolates were not susceptible to ketoconazole and itraconazole, with only 5 (45%) to fluconazole. In line with results of other relevant studies, we documented that a considerable proportion of Candida b...Continue Reading

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Citations

Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R AndesUNKNOWN Mycoses Study Group
Mar 10, 2016·Frontiers in Microbiology·Chaminda J SeneviratneLijian Jin
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Oct 8, 2016·Advanced Biomedical Research·Naeimeh FathiSeyedeh Zahra Sadrossadati
Sep 3, 2013·Indian Journal of Microbiology·Sheetal U HarakuniNadeemaktar Jamadar

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