Candida auris: Epidemiology, biology, antifungal resistance, and virulence

PLoS Pathogens
Han DuGuanghua Huang

Abstract

First described in 2009 in Japan, the emerging multidrug-resistant fungal pathogen Candida auris is becoming a worldwide public health threat that has been attracting considerable attention due to its rapid and widespread emergence over the past decade. The reasons behind the recent emergence of this fungus remain a mystery to date. Genetic analyses indicate that this fungal pathogen emerged simultaneously in several different continents, where 5 genetically distinct clades of C. auris were isolated from distinct geographical locations. Although C. auris belongs to the CTG clade (its constituent species translate the CTG codon as serine instead of leucine, as in the standard code), C. auris is a haploid fungal species that is more closely related to the haploid and often multidrug-resistant species Candida haemulonii and Candida lusitaniae and is distantly related to the diploid and clinically common fungal pathogens Candida albicans and Candida tropicalis. Infections and outbreaks caused by C. auris in hospitals settings have been rising over the past several years. Difficulty in its identification, multidrug resistance properties, evolution of virulence factors, associated high mortality rates in patients, and long-term survi...Continue Reading

References

Dec 1, 1987·Journal of Bacteriology·J M Anderson, D R Soll
Jun 1, 1995·The Journal of Hospital Infection·M A Pfaller
Sep 6, 2002·Microbiology·Salil A LachkeDavid R Soll
Mar 26, 2004·Nature Reviews. Microbiology·Luanne Hall-StoodleyPaul Stoodley
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
May 18, 2007·Annual Review of Microbiology·Malcolm Whiteway, Catherine Bachewich
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Subhrajit BiswasAsis Datta
Dec 25, 2007·Nature Reviews. Microbiology·Sheryl S JusticeScott J Hultgren
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi-Na KimDong Wook Ryang
Mar 31, 2009·Current Biology : CB·Rebecca S ShapiroLeah E Cowen
Sep 22, 2009·Current Fungal Infection Reports·Neena JainBettina C Fries
May 27, 2011·American Journal of Botany·Meredith Blackwell
Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Aug 9, 2011·Comptes rendus biologies·Manuel A S SantosGabriela R Moura
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kaitlyn C GrayMartin D Burke
Apr 14, 2012·Nature·Matthew C FisherSarah J Gurr
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
Feb 1, 2013·Nature·Meleah A HickmanJudith Berman
Mar 20, 2013·Indian Journal of Medical Microbiology·S SarmaA Rattan
Sep 21, 2013·Emerging Infectious Diseases·Anuradha ChowdharyJacques F Meis
Dec 21, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A ChowdharyJ F Meis
Jun 26, 2014·Emerging Infectious Diseases·Rindidzani E MagoboNelesh P Govender
Sep 9, 2015·BMC Genomics·Sharanya ChatterjeeUtpal S Tatu
Oct 22, 2015·Annual Review of Microbiology·Clarissa J Nobile, Alexander D Johnson
Jul 28, 2016·The Journal of Infection·Belinda CalvoArnaldo Lopes Colombo
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shawn R LockhartAnastasia P Litvintseva
Jan 19, 2017·Emerging Infectious Diseases·Leighann SherryRiina Rautemaa-Richardson
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Shivaprakash M RudramurthyAnup Ghosh
May 26, 2017·Journal of Clinical Microbiology·Milena KordalewskaDavid S Perlin
Sep 25, 2017·The Journal of Hospital Infection·M BiswalA Chakrabarti
Nov 17, 2017·Clinical Microbiology Reviews·Anna Jeffery-SmithColin S Brown
Nov 22, 2017·Antimicrobial Agents and Chemotherapy·Ruvini U PathiranaMira Edgerton
Nov 24, 2017·Journal of Clinical Microbiology·Emily S Spivak, Kimberly E Hanson
Dec 6, 2017·The Journal of Hospital Infection·R KeanG Ramage
Feb 2, 2018·The Journal of Infectious Diseases·Frederic Lamoth, Dimitrios P Kontoyiannis
Apr 11, 2018·Antimicrobial Agents and Chemotherapy·Milena KordalewskaDavid S Perlin

❮ Previous
Next ❯

Citations

Apr 4, 2021·Journal of Fungi·Anuja Paudyal, Govindsamy Vediyappan
Apr 28, 2021·Current Biology : CB·Nicolas PaponGustavo H Goldman
May 1, 2021·International Journal of Molecular Sciences·Lucia ČernákováCélia F Rodrigues
May 4, 2021·Frontiers in Cellular and Infection Microbiology·Sabrina JenullKarl Kuchler
May 23, 2021·FEMS Yeast Research·Ana Rita BezerraManuel A S Santos
Jun 3, 2021·Journal of Fungi·Silvia Katherine CarvajalPatricia Escandón
Jun 20, 2021·Revista iberoamericana de micología·Alba Ruiz-Gaitán, José Luis Del Pozo
Jun 22, 2021·Applied Microbiology and Biotechnology·Qian ZhangZhangyong Song
Jul 2, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Katharina LastUNKNOWN Trainee Association of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Jul 8, 2021·Expert Opinion on Pharmacotherapy·Adam G Stewart, David L Paterson
Aug 24, 2021·Clinical and Experimental Medicine·Amir AbdoliAzra Kenarkoohi
Aug 28, 2021·Critical Care : the Official Journal of the Critical Care Forum·Michael S NiedermanGirish B Nair
Aug 27, 2021·Journal of Fungi·Hannah M Edwards, Johanna Rhodes
Oct 15, 2021·Nature Reviews. Microbiology·Rachel E BakerC Jessica E Metcalf
Nov 2, 2021·Frontiers in Cellular and Infection Microbiology·Dingchen LiLi Han
Dec 3, 2021·Mycopathologia·Fatemeh SafariHossein Mirhendi
Dec 11, 2021·Emerging Microbes & Infections·Victor Garcia-BustosAmparo Ruiz-Saurí
Oct 12, 2021·Antimicrobial Agents and Chemotherapy·Benjamin WilliamsonKelley R Healey

❮ Previous
Next ❯

Methods Mentioned

BETA
environmental stresses

Software Mentioned

RAxML

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Ilan S Schwartz, T C Dingle
JAMA : the Journal of the American Medical Association
Suzanne F Bradley
JAMA : the Journal of the American Medical Association
Suzanne F Bradley
© 2022 Meta ULC. All rights reserved