PMID: 11320905Apr 26, 2001Paper

Candida ciferrii, a new fluconazole-resistant yeast causing systemic mycosis in immunocompromised patients

Annals of Hematology
E GunsiliusA L Petzer

Abstract

Systemic infections related to fluconazole-resistant yeasts are increasingly observed in immunocompromised patients receiving fluconazole as a prophylactic antifungal treatment. Here, we report a case of invasive candidiasis caused by Candida ciferrii in a patient with acute myeloid leukemia and who suffered a relapse after autologous peripheral blood progenitor cell transplantation. Erythematous skin papulae and spotted pulmonary infiltrations were present. A skin biopsy led to the diagnosis of invasive candidiasis, emphasizing the diagnostic usefulness of this procedure. The yeast was identified as Candida ciferrii and in vitro susceptibility testing revealed its resistance to fluconazole. Until now, Candida ciferrii has not been known to cause invasive fungal infections in humans. Thus, we add another fungus to the list of flucanozole-resistant yeasts and suggest that in vitro susceptibility testing of isolated fungi should be performed for the selection of appropriate antimycotic drugs.

Citations

Feb 6, 2004·Diagnostic Microbiology and Infectious Disease·Ming-Fang ChengHsiu-Jung Lo
Mar 20, 2010·Journal of Clinical Microbiology·Emilio Cendejas-BuenoManuel Cuenca-Estrella
Jul 29, 2015·Tropical Medicine & International Health : TM & IH·Kee Peng NgRukumani Devi Velayuthan
Apr 28, 2010·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Hironobu SokiKen Kikuchi
Oct 17, 2015·Indian Journal of Medical Microbiology·M R CapoorH C Sachdeva
Jul 21, 2021·Ocular Immunology and Inflammation·Pooja BansalPoonam Loomba

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