Candida parapsilosis: from Genes to the Bedside

Clinical Microbiology Reviews
Renáta TóthAttila Gácser

Abstract

Patients with suppressed immunity are at the highest risk for hospital-acquired infections. Among these, invasive candidiasis is the most prevalent systemic fungal nosocomial infection. Over recent decades, the combined prevalence of non-albicans Candida species outranked Candida albicans infections in several geographical regions worldwide, highlighting the need to understand their pathobiology in order to develop effective treatment and to prevent future outbreaks. Candida parapsilosis is the second or third most frequently isolated Candida species from patients. Besides being highly prevalent, its biology differs markedly from that of C. albicans, which may be associated with C. parapsilosis' increased incidence. Differences in virulence, regulatory and antifungal drug resistance mechanisms, and the patient groups at risk indicate that conclusions drawn from C. albicans pathobiology cannot be simply extrapolated to C. parapsilosis Such species-specific characteristics may also influence their recognition and elimination by the host and the efficacy of antifungal drugs. Due to the availability of high-throughput, state-of-the-art experimental tools and molecular genetic methods adapted to C. parapsilosis, genome and transcrip...Continue Reading

References

Jan 1, 1985·Annual Review of Medicine·J G Gerber, A S Nies
Jan 1, 1986·Biology of the Cell·N CamougrandM Guerin
Jan 1, 1986·Molecular and Cellular Biology·M B KurtzD R Kirsch
Jan 1, 1987·Molecular and Cellular Biology·R KellyD R Kirsch
Aug 1, 1974·Journal of General Microbiology·N C Khan, S P Sen
Aug 1, 1974·The Journal of Infectious Diseases·P D HoeprichM J Winship
Oct 1, 1972·The Journal of Clinical Investigation·R I Lehrer
Jan 1, 1984·Molecular & General Genetics : MGG·L KovácP P Slonimski
Nov 1, 1984·Reviews of Infectious Diseases·R A SmegoD T Durack
Jan 1, 1983·The Journal of Infectious Diseases·S M SeidenfeldP A Mackowiak
Apr 10, 1995·Molecular & General Genetics : MGG·J NosekH Fukuhara
Jan 1, 1995·Diagnostic Microbiology and Infectious Disease·M A PfallerR J Hollis
Aug 25, 1993·Nucleic Acids Research·T OhamaT Nakase
Jan 1, 1993·The American Journal of Medicine·A R TunkelB Wispelwey
Apr 29, 1998·The American Journal of Medicine·E J AnaissieS Vartivarian
Jun 5, 1998·Trends in Genetics : TIG·J NosekL Kovác
Mar 6, 1999·Current Opinion in Microbiology·A P Mitchell
Jan 11, 2000·Clinical Microbiology Reviews·M A Ghannoum
Dec 19, 2001·Infection and Immunity·Mairi C NoverrGary B Huffnagle

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Citations

Aug 23, 2019·MSphere·Dhirendra Kumar SinghAttila Gácser
Aug 23, 2019·Der Internist·C SchroederS von Vietinghoff
Jun 12, 2020·Frontiers in Cellular and Infection Microbiology·Cecilia MartiniMaurizio Sanguinetti
May 1, 2020·Journal of Fungi·Tanmoy ChakrabortyAttila Gácser
Aug 23, 2020·Journal of Fungi·Amir ArastehfarDavid S Perlin
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asta JudzentieneRasa Garjonyte
May 21, 2020·Frontiers in Cellular and Infection Microbiology·Jesús GuineaPilar Escribano
Aug 11, 2019·Applied and Environmental Microbiology·Ágnes JakabRenátó Kovács
Sep 2, 2020·Journal of Fungi·Laura C García-CarneroHéctor M Mora-Montes
Apr 2, 2020·Frontiers in Cellular and Infection Microbiology·Dhirendra Kumar SinghAttila Gácser
Jul 2, 2020·Infection and Drug Resistance·Manuela Gómez-Gaviria, Héctor M Mora-Montes
Feb 6, 2020·International Journal of Molecular Sciences·Jiří DostálIva Pichová
Jan 16, 2021·Journal de mycologie médicale·Eliane Martins da SilvaTerezinha I E Svidzinski
Jan 13, 2021·Journal of Fungi·Emilia Gómez-MoleroOliver Bader
Mar 18, 2021·Virulence·Tibor NémethAttila Gacser
Jul 25, 2020·Microbial Pathogenesis·Carlos Fernando Odir Rodrigues MeloRodrigo Ramos Catharino
Apr 13, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Jiří DostálMartin Lepšík
Feb 12, 2020·Trends in Microbiology·Nicolas PaponChristophe d'Enfert
Apr 29, 2021·BMJ Case Reports·Maria A Parekh, Vitor H Pacheco
Nov 7, 2020·Future Microbiology·Thainá V da SilvaRondinelli D Herculano
May 12, 2021·International Journal of Laboratory Hematology·Samuel Ricardo ComarAna Paula de Azambuja

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