Candida pneumonia in intensive care unit?

Open Forum Infectious Diseases
Ronny M SchnabelDennis Bergmans

Abstract

It has been questioned if Candida pneumonia exists as a clinical entity. Only histopathology can establish the definite diagnosis. Less invasive diagnostic strategies lack specificity and have been insufficiently validated. Scarcity of this pathomechanism and nonspecific clinical presentation make validation and the development of a clinical algorithm difficult. In the present study, we analyze whether Candida pneumonia exists in our critical care population. We used a bronchoalveolar lavage (BAL) specimen database that we have built in a structural diagnostic approach to ventilator-associated pneumonia for more than a decade consisting of 832 samples. Microbiological data were linked to clinical information and available autopsy data. We searched for critically ill patients with respiratory failure with no other microbiological or clinical explanation than exclusive presence of Candida species in BAL fluid. Five cases could be identified with Candida as the likely cause of pneumonia.

References

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Citations

Apr 27, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J C Hurley
Sep 8, 2016·Heart & Lung : the Journal of Critical Care·Meagan GriffinKelly E Martin
Jul 11, 2016·European Journal of Internal Medicine·Spinello AntinoriMario Corbellino
Mar 20, 2018·Journal of Intensive Care Medicine·Justin K LuiScott E Kopec
Jan 28, 2021·Journal of Fungi·Jasminka TalapkoIvana Škrlec
Apr 15, 2021·The Journal of Hospital Infection·Danielle L SilvaDaniel A Santos

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Methods Mentioned

BETA
bronchoalveolar
bronchoalveolar lavage
hysterectomy
biopsy
biopsies

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