Candida rugosa: a possible emerging cause of candidaemia in trauma patients.

Infection
Bijayini BeheraM C Misra

Abstract

Candida rugosa appears to be emerging as a distinctive cause of candidaemia in recent years. Candidaemia due to this species is important to recognise because of its decreased susceptibility to azoles. We retrospectively evaluated a cluster of C. rugosa candidaemia occurring in critically ill trauma patients from a level I trauma centre of India. During the period from July 2008 to September 2009, a total of 28 blood samples from 19 patients were found to be positive for C. rugosa. Genetic relatedness among 17 C. rugosa isolates were characterised by the random amplified polymorphic DNA (RAPD) assay using M13 primers. These isolates were also characterised for their susceptibility to four antifungal agents, amphotericin B, fluconazole, flucytosine and voriconazole. In our study, 21% of C. rugosa isolates were resistant to fluconazole, whereas 100% susceptibility to amphotericin B, flucytosine and voriconazole was noted. Thirteen out of the 19 patients (68.4%) with C. rugosa candidaemia died. Of these, six had received antifungal therapy after confirmation of fungaemia. Prior to this cluster, C. rugosa had never been identified as a cause of infection at our centre. Due to the retrospective nature of the evaluation of these case...Continue Reading

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Citations

Jul 27, 2011·Medical Mycology Journal·Takashi Sugita, Masako Takashima
Aug 28, 2012·Journal of Laboratory Physicians·Neetu JainSatya Priya Sharma
Jun 3, 2014·BMC Complementary and Alternative Medicine·Beauty E OmoruyiGraeme Bradley
Dec 27, 2015·Medical Mycology·Gloria AdjapongAshley Garrill
Jan 8, 2011·Journal of Medical Microbiology·Richard C Barton
Oct 29, 2013·Fungal Genetics and Biology : FG & B·Ana Carolina Barbosa PadovanArnaldo Lopes Colombo
Jun 28, 2016·Diagnostic Microbiology and Infectious Disease·Marta SanchisJavier Capilla
Aug 6, 2019·Frontiers in Microbiology·Minh Thuy Vi HoangWieland Meyer
Oct 28, 2019·Current Topics in Medicinal Chemistry·Laura Nunes SilvaAndré Luis Souza Dos Santos
Apr 11, 2018·Medical Mycology·Chunyan MingYingqian Kang

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