Candida species biofilm and Candida albicans ALS3 polymorphisms in clinical isolates

Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]
Ariane Bruder-NascimentoEduardo Bagagli

Abstract

Over the last decades, there have been important changes in the epidemiology of Candida infections. In recent years, Candida species have emerged as important causes of invasive infections mainly among immunocompromised patients. This study analyzed Candida spp. isolates and compared the frequency and biofilm production of different species among the different sources of isolation: blood, urine, vulvovaginal secretions and peritoneal dialysis fluid. Biofilm production was quantified in 327 Candida isolates obtained from patients attended at a Brazilian tertiary public hospital (Botucatu, Sao Paulo). C. albicans ALS3 gene polymorphism was also evaluated by determining the number of repeated motifs in the central domain. Of the 198 total biofilm-positive isolates, 72 and 126 were considered as low and high biofilm producers, respectively. Biofilm production by C. albicans was significantly lower than that by non-albicans isolates and was most frequently observed in C. tropicalis. Biofilm production was more frequent among bloodstream isolates than other clinical sources, in urine, the isolates displayed a peculiar distribution by presenting two distinct peaks, one containing biofilm-negative isolates and the other containing isol...Continue Reading

Citations

Sep 21, 2015·Biotechnology Letters·Shilpi Srivastava, Atul Bhargava
Jun 7, 2017·Antimicrobial Agents and Chemotherapy·Rui-Huan LiuLing-Yi Kong
Jun 4, 2019·Canadian Journal of Microbiology·Da-Seul Shin, Yong-Bin Eom
May 18, 2021·Frontiers in Microbiology·Keke DengXuequn Zhao

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Methods Mentioned

BETA
PCR
genoR

Software Mentioned

Blast
Mega
AlphaEase R
Chromas

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