Candidacidal activity of a monoclonal antibody that binds with glycosyl moieties of proteins of Candida albicans

Medical Mycology
Amol Kavishwar, P K Shukla

Abstract

The incidence of life threatening mycoses caused by opportunistic fungi has increased dramatically in recent years with Candida and Aspergillus being the most commonly encountered species. Candida albicans ranks among the four most common causes of bloodstream infections and is responsible for vulvovaginal candidiasis in the majority of women in their reproductive years. Limited spectrum of antifungal activity of currently available antifungals and emergence of resistance has become a serious problem. Therefore, in search of an alternative form of treatment of candidiasis, in the present study a monoclonal antibody (MAb-G5) of IgA isotype was identified from the hybridoma produced by the fusion of lymphocytes of C. albicans immunized mouse with Sp2/O cells. The MAb-G5 exhibited in vitro candidacidal activity and was also found to be useful for treatment and prophylactic use under experimental conditions in vivo.

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Citations

Jan 29, 2008·The Lancet Infectious Diseases·Antonio Cassone
Apr 27, 2011·Antimicrobial Agents and Chemotherapy·Sonia BrenaJosé Pontón
Aug 13, 2011·Clinical and Vaccine Immunology : CVI·Hong Xin, Jim E Cutler
Jul 20, 2010·Immunotherapy·Jonathan CabezasJosé Pontón
Aug 6, 2011·Immunological Investigations·James Isami Ito
Jun 17, 2016·Cellular Microbiology·Ema PaulovičováNikolay E Nifantiev
Dec 23, 2006·Expert Review of Vaccines·Antonio Cassone, Antonella Torosantucci
Feb 9, 2020·Journal of Fungi·Sebastian Ulrich, Frank Ebel
Dec 4, 2012·Journal of the American Podiatric Medical Association·Nancy L Parsley, Ilene B Harris

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