Candidate biomarkers for acute rejection of pregnancy after in-utero cell-based therapy in pre-immune embryos via ultrasound-guided celocentesis.

American Journal of Reproductive Immunology : AJRI
Jacobo L SantolayaJoaquín Santolaya-Forgas

Abstract

A maternal serum biomarker profile analysis was performed to determine potential indicators of acute rejection of pregnancy following in-utero cell-based treatments in pre-immune embryos. We used an established non-human primate model for in-utero stem cell therapy at 38-42 days from fertilization. The maternal serum concentrations of nine candidate biomarkers for acute rejection of pregnancy were determined before and after the injection of different cocktails of human umbilical cord blood stem cells into the gestational sac. All animals were then followed until delivery. Twenty-four hours after celocentesis, two of the animals aborted. These two animals received a cocktail of haemopoietic stem cells with the highest concentration of human CD3(+) cells and showed a twofold increase in maternal serum IL-6 and a threefold increase in prolactin after the procedure. The remaining six animals delivered at term live and normal newborns and only demonstrated an increase in prolactin after the celocentesis procedure. IL-6 and prolactin are master immunoregulators with pleiotropic biological functions that have different maternal serum concentrations depending on pregnancy outcome. These findings suggest that increases in maternal ser...Continue Reading

References

Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Oct 19, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Isabel GalanGiancarlo Mari
May 8, 2007·American Journal of Perinatology·Joaquin Santolaya-ForgasLouise Wilkins-Haugh
Jun 15, 2007·Ultrasound in Medicine & Biology·Joaquin Santolaya-ForgasRoman Wolf
Aug 12, 2009·Journal of Reproductive Immunology·L ArruvitoL Fainboim
Jun 10, 2010·American Journal of Reproductive Immunology : AJRI·Amolak Singh Bansal
Feb 3, 2011·Clinical Reviews in Allergy & Immunology·Hedi OrbachYehuda Shoenfeld
Nov 24, 2011·Clinical & Developmental Immunology·Shyi-Jou ChenHuey-Kang Sytwu
Dec 14, 2011·Autoimmunity Reviews·Shahar ShellyHedi Orbach
Jan 10, 2012·Cell·Masahito TachibanaShoukhrat Mitalipov

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