Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan

Personalized Medicine
Basima A AlmomaniAmy J McKnight

Abstract

To evaluate whether SNPs (n = 15) in ten candidate genes (ADRB2, ADH5, ARGI, CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma in Jordanian population of Arab descent. A case-control study included 245 adult asthmatics and 249 controls. Significant genetic association was identified at the rs2236647 (T/C) SNP in STIP1 and risk of asthma (p < 0.001). The C allele and CC genotype of this SNP were significantly higher in asthmatics compared with controls. The rs1141370 SNP (Val34Met) in ADRB2 is not polymorphic in our cohort. The rs2236647 SNP could act as a reliable tool to identify individuals at risk of developing asthma and provision of early intervention in population of Arab descent.

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Citations

Sep 14, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mariem SalhiAgnes Hamzaoui

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Methods Mentioned

BETA
genotyping
protein folding

Software Mentioned

Haploview
Statistical Package for Social Sciences ( SPSS

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